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Table 1 Anti-plasmodial activity (IC 50 ) and cytotoxicity (CC 50 ) of HSCCC fractions of Annickia kummeriae methanolic leaf extract

From: Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)

Fraction Wt (mg) P. falciparum K1 IC50(μg/ml) Cytotoxicity CC50(μg/ml) SI IC50fr. IC50CQ IC50fr. IC50Art IC50fr. IC50Pdx
AKLM 15,000 0.12 ± 0.01 30.0 ± 0.8 250 1.9 60 3,333
AKLM1 562 5.0 ± 0.31 >90.0 >18 79.4 2500 >10,000
AKLM2 2,999 0.87 ± 0.1 20.0 ± 3.3 23 13.8 435 2,222
AKLM3 1,534 3.01 ± 0.81 78.0 ± 5.4 26 47.8 1,505 8,667
AKLM 4 157 1.34 ± 0.33 76.0 ± 1.44 57 21.3 670 8,444
AKLM 5 249 3.6 ± 0.2 >90.0 >25 57.1 1,800 >10,000
AKLM 6 427 0.45 ± 0.15 59.0 ± 1.5 131 7.1 225 6,556
AKLM 7 165 0.11 ± 0.02 >90.0 >818 1.7 55 >10,000
AKLM 8 221 0.09 ± 0.04 >90.0 >1,000 1.4 45 >10,000
AKLM 9 680 0.06 ± 0.02 >90.0 >1,500 1.0 30 >10,000
AKLM 10 1,295 0.05 ± 0.02 >90.0 >1,800 0.8 25 >10,000
AKLM 11 1,679 0.05 ± 0.01 >90.0 >1,800 0.8 25 >10,000
AKLM 12 1,056 0.06 ± 0.03 >90.0 >1,500 1.0 30 >10,000
AKLM 13 878 0.62 ± 0.4 >90.0 >145 9.8 310 >10,000
AKLM 14 948 1.0 ± 0.22 >90.0 >90 15.9 500 >10,000
AKLM 15 1,232 0.13 ± 0.02 >90.0 >692 2.1 65 >10,000
AKLM 16 416 0.09 ± 0.03 84.0 ± 3.91 933 1.4 45 9,333
AKLM 17 498 1.67 ± 0.43 >90.0 >54 26.5 835 >10,000
  1. Fr. – HSCCC fraction of Annickia kummeriae leaves methanolic extract, P. falciparum K1 used for anti-plasmodial assays, rat myoblast L-6 cells used for cytotoxicity assays, CQ chloroquine (IC50 0.063 ± 0.034 μg/ml), Art artemisinin (IC50 0.002 ± 0.00001 μg/ml), Pdx podophyllotoxin (IC50 0.009 ± 0.003 μg/ml).