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Figure 4 | BMC Complementary and Alternative Medicine

Figure 4

From: Ganghwaljetongyeum, an anti-arthritic remedy, attenuates synoviocyte proliferation and reduces the production of proinflammatory mediators in macrophages: the therapeutic effect of GHJTY on rheumatoid arthritis

Figure 4

GHJTY decreases the LPS-increased production of NO, TNF-α, and IL-12 in RAW264.7 cells. RAW264.7 cells were pretreated with GHJTY for 2 hours and then incubated with LPS for 18 hours. (A) LPS-induced NO production in RAW264.7 cells was blocked by GHJTY pretreatment. Inflammatory cytokines were measured in the cell supernatants by ELISA. GHJTY decreased the LPS-induced production of TNF-α (B) and IL-12 (C) cytokines. ++ P < 0.01 and +++ P < 0.001: compared with non-treated group, * P < 0.05, ** P < 0.01, and *** P < 0.001: compared with LPS-treated group.

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