GHJTY reduces the IL-1β-induced NF- κB activation in HIG-82 cells. HIG-82 cells were transfected with a reporter plasmid, pNF-κB-luciferase. IL-1β increased NF- κB transcription, which was blocked by GHJTY at a concentration of 1.0 mg/ml. Celecoxib (Cel) also blocked IL-1β-induced NF-κB activation in HIG-82 cells. * P < 0.05 and ** P < 0.01: compared with IL-1β treated group.