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Table 4 Changes in body weight and biochemical parameters after 14 days of treatment with C . aurantium EO

From: Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment

Treatment n Body weight (g) Biochemical parameters
   Day 1 Day 14 UR (mg/dL) CR (mg/dL) TPRO (g/dL) ALB (g/dL) AST (UI/L) AP (UI/L) CHOL (mg/dL) TRGL (mg/dL)
Tween 6 35 ± 4 43 ± 7 64.5 ± 10.1 0.3 ± 0.1 7.0 ± 0.1 3.9 ± 0.3 320.4 ± 85.5 164.8 ± 74.2 158.8 ± 35.2 173.8 ± 42.5
EO 1 mg/kg 7 34 ± 6 41 ± 10 64.4 ± 13.7 0.3 ± 0.2 7.9 ± 1.9 4.5 ± 0.9 334.2 ±5 2.7 131.4 ± 44.7 131.4 ± 27.2 143.6 ± 50.8
EO 5 mg/kg 6 34 ± 2 42 ± 4 65.3 ± 13.7 0.2 ± 0.1 6.9 ± 0.8 4.2 ± 0.9 377.4 ± 83.6 161.9 ± 64.0 135.2 ± 15.6 130.8 ± 37.5
EO 10 mg/kg 7 34 ± 4 40 ± 5 64.1 ± 11.9 0.2 ± 0.0 6.9 ± 0.6 3.9 ± 0.4 309.5 ± 45.2 123.3 ± 34.9 121.9 ± 20.4 * 132.7 ± 33.4
  1. The data are presented as the mean ± SD. UR (urea), CR (creatinine), TPRO (total protein), ALB (albumin), AST (aspartate aminotransferase), AP (alkaline phosphatase), CHOL (cholesterol), TRGL (triglycerides). * p ≤ 0.05 in relation to the control group (one-way ANOVA followed by the Dunnett’s Multiple Comparisons Test).