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Table 3 Effects of oral or inhaled C . aurantium EO on immobility time (s) in the forced swim test

From: Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment

Oral route Inhalatory route
Treatment n Immobility (s) Treatment n Immobility (s)
TW 5 226 (225–231) SAL 5 207 (203–219)
IM 6 156 (120–165) * IM 6 167 (164–171) *
EO 1 mg/kg 6 222 (215–238) EO 0.5% 8 215 (207–221)
EO 5 mg/kg 7 234 (217–241) EO 1.0% 8 194 (179–208)
EO 10 mg/kg 8 238(224–255) EO 2.5% 8 220 (175–234)
EO 50 mg/kg 6 217 (206–222)    
  1. The data are expressed as the median and interquartile range (Q1-Q3). TW: vehicle; SAL: isotonic saline solution; IM: imipramine hydrochloride, 30 mg/kg (i.p.); EO: C. aurantium essential oil. * p ≤ 0.05 in relation to the corresponding TW or SAL group (Kruskal-Wallis followed by Mann-Whitney U-Test).