Skip to main content

Table 2 Effects of distinct treatments on motor coordination as evaluated by the rotarod test

From: Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment

Acute treatment Repeated treatment
Group Fraction Group Fraction Group Fraction
TW 0.01% 1/7 FLU 2 0/5 TW 0.01% 0/5
DZP 1 0/8 WAY 0.5 1/5 BUSP 10 0/6
EO 1 0/5 DZP 1 + FLU 2 0/4 EO 1 0/5
EO 5 0/8 WAY 0.5 + DZP 1 1/5 EO 5 0/5
EO 10 1/6 EO 5 + FLU 2 0/4 EO 10 0/7
EO 50 0/6 WAY 0.5 + EO 5 0/5   
  1. The data are presented as the fraction of the total number of animals in each experimental group that were unable to perform the test after acute or repeated (14 days) treatments. TW: vehicle; DZP: diazepam; OE: C. aurantium essential oil; BUSP: buspirone; FLU: flumazenil; WAY: WAY100635. The doses are presented in mg/kg. The differences were compared in relation to the TW group using Fisher’s exact test.