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Table 4 Effects of XCHD on MDA, ONOO - , VMA, LPS-P, ALP-A and ALP-C in the gut, liver and brain

From: Xiaochaihu Decoction attenuates the vicious circle between the oxidative stress and the ALP inactivation through LPS-catecholamines interactions in gut, liver and brain during CCI4+ethanol-induced mouse HCC

Groups

Dose (g.kg-1)

Gut (n)

Liver (n)

Brain (n)

MDA (nmol/L/g)

    

Normal

-

5.48±1.78(6)

300.86±29.16(6)

68.34±13.22(6)

HCC

-

62.75±19.80(9)b

318.21±23.27(6)

126.39±30.92(8)b

HCC+LDSD

-

171.67±42.24d

360.87±48.02(6)c

180.72±27.05(8)d

XCHD

8

58.69±17.99f

319.75±19.28(7)

127.06±24.33(8)

ONOO - (mmol/L/g)

    

Normal

-

7.39±0.66(6)

12.87±0.95(6)

3.99±24.33(8)f

HCC

-

10.61±0.85(13)b

16.40±0.80(13)b

7.46±1.42(13)b

HCC+LDSD

-

15.19±1.78(9)

19.86±0.80(9)

12.90±0.48(9)d

XCHD

8

10.31±1.12(14)f

14.15±0.92(9)

12.90±0.48(9)

VMA (ug/ml/g)

    

Normal

-

6.78±1.09(6)

32.46±5.64(6)

1.76±0.96(6)

HCC

-

9.94±0.10b

51.01±5.06(9)b

3.99±0.46(6)b

HCC+LDSD

-

19.79±0.28(6)d

86.66±5.06(9)d

11.81±6.60(6)c

XCHD

8

10.52±0.56(6)b

74.38±10.20(14)f

2.92±2.82(6)f

LPS-P (mmol/L/g)

    

Normal

-

0.55±0.04(6)

0.36±0.11(6)

0.052±0.003(6)

HCC

-

0.66±0.06(6)b

0.86±0.09(13)b

0.060±0.004(6)b

HCC+LDSD

-

0.76±0.06(6)d

1.30±0.43(6)d

0.075±0.003(6)d

XCHD

8

0.57±0.05(6)f

0.71±0.12(14)f

0.059±0.009(6)f

ALP-A (μ)

    

Normal

-

131.98±30.86(6)

140.17±8.74(6)

29.60±2.41(6)

HCC

-

55.52±8.87(6)b

53.70±7.78(6)b

27.75±4.66(6)b

HCC+LDSD

-

35.94±8.77(6)d

38.73±7.78(6)d

20.27±±4.65(6)d

XCHD

8

94.16±12.35(6)f

64.13±7.52(6)f

39.37±6.12(6)f

ALP-C (%)

    

Normal

-

8.69±3.75(6)

10.01±1.24(6)

26.06.70(6)

HCC

-

47.32±14.75(6)b

56.89±9.98(6)b

37.84±6.95(6)b

HCC+LDSD

-

78.47±18.41(6)d

75.37±14.87(6)c

80.0±5.28(6)d

XCHD

8

20.73±4.82(6)f

32.73±4.49(6)f

45.73±11.43(6)

  1. aP <0.05, bP<0.01 Compare with normal; cP <0.05, dP <0.01 Compare with HCC; eP <0.05, fP <0.01 Compare with HCC+LDSA.