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Table 1 Effects of polyherbal formulations (ZPTO and ZTO) on serum lipids and glucose levels in atherogenic diet-fed Sprague Dawley rats

From: Studies on two polyherbal formulations (ZPTO and ZTO) for comparison of their antidyslipidemic, antihypertensive and endothelial modulating activities

Parameters ND AD AD + 3% ZPTO AD + 3% ZTO
Total Cholesterol (mg/dl) 74.62 ± 3.9 390.5 ± 3.09 ### 110.3 ± 12.14*** 110.7 ± 10.24***
HDL-C (mg/dl) 38.54 ± 1.7 27.82 ± 2.97 30.91 ± 3.1 82.6 ± 11.45***
LDL-C (mg/dl) 24.9 ± 2.8 304 ± 35.7 ### 74.5 ± 9.4*** 57.24 ± 10.8***
Triglycerides (mg/dl) 59.7 ± 4.2 65.2 ± 6.4 71.6 ± 11.6 49.5 ± 11.8
Atherogenic Index 0.92 ± 0.12 16.96 ± 3.15### 3.53 ± 0.813** 0.7 ± 0.155***
Glucose (mg/dl) 95.6 ± 7.2 147.5 ± 4.8 ### 94.18 ± 6.96*** 130.3 ± 3.15**
Daily diet consumption (g/Kg/day) 186.5 ± 11.8 161.8 ± 12.4# 78.9 ± 10.8*** 121.9 ± 7.1***
% Change in body weight 33.33 ± 1.6 56.8 ± 1.97### 53.2 ± 0.8 46.51 ± 1.61**
  1. Normal Diet (ND) administered Sprague Dawley rats (SD), Atherogenic Diet (AD) administered SD rats; Polyherbal formulations, ZTO and ZPTO are composed of Zingiber officinalis (Z), Terminalia belerica (T), Orchis mascula, or/and Piper nigrum (P); Values shown are Mean ± S.E.M. of 7–10 determinations.
  2. #p <0.05 and ###p <0.001 compared to ND (Student t-test).
  3. ** p <0.01 and *** p <0.001 compared to AD (One-way ANOVA followed by Dunnett’s multiple comparison-test).