Studies on two polyherbal formulations (ZPTO and ZTO) for comparison of their antidyslipidemic, antihypertensive and endothelial modulating activities

Table 1 Effects of polyherbal formulations (ZPTO and ZTO) on serum lipids and glucose levels in atherogenic diet-fed Sprague Dawley rats

Parameters	ND	AD	AD + 3% ZPTO	AD + 3% ZTO
Total Cholesterol (mg/dl)	74.62 ± 3.9	390.5 ± 3.09 ###	110.3 ± 12.14***	110.7 ± 10.24***
HDL-C (mg/dl)	38.54 ± 1.7	27.82 ± 2.97	30.91 ± 3.1	82.6 ± 11.45***
LDL-C (mg/dl)	24.9 ± 2.8	304 ± 35.7 ###	74.5 ± 9.4***	57.24 ± 10.8***
Triglycerides (mg/dl)	59.7 ± 4.2	65.2 ± 6.4	71.6 ± 11.6	49.5 ± 11.8
Atherogenic Index	0.92 ± 0.12	16.96 ± 3.15###	3.53 ± 0.813**	0.7 ± 0.155***
Glucose (mg/dl)	95.6 ± 7.2	147.5 ± 4.8 ###	94.18 ± 6.96***	130.3 ± 3.15**
Daily diet consumption (g/Kg/day)	186.5 ± 11.8	161.8 ± 12.4#	78.9 ± 10.8***	121.9 ± 7.1***
% Change in body weight	33.33 ± 1.6	56.8 ± 1.97###	53.2 ± 0.8	46.51 ± 1.61**

Normal Diet (ND) administered Sprague Dawley rats (SD), Atherogenic Diet (AD) administered SD rats; Polyherbal formulations, ZTO and ZPTO are composed of Zingiber officinalis (Z), Terminalia belerica (T), Orchis mascula, or/and Piper nigrum (P); Values shown are Mean ± S.E.M. of 7–10 determinations.
^#p <0.05 and ^###p <0.001 compared to ND (Student t-test).
** p <0.01 and *** p <0.001 compared to AD (One-way ANOVA followed by Dunnett’s multiple comparison-test).

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