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Table 3 Effect of oral administration of curcumin for six weeks on lipid peroxidation, reduced glutathione and antioxidant enzyme activities in streptozotocin induced diabetic rats

From: Curcumin regulates gene expression of insulin like growth factor, B-cell CLL/lymphoma 2 and antioxidant enzymes in streptozotocin induced diabetic rats

  Group I Group II Group III
TBARS (μM) 34.6 ± 0.05 42.9 ± 0.1* 32.6 ± 0.09#
CAT (nmol/min/gram tissue) 23.2 ± 0.10 32.6 ± 0.2* 31.1 ± 1.50*
SOD (U/gram tissue) 6.1 ± 0.03 7.2 ± 0.1* 8.3 ± 0.07*#
GPX (nmol/min/ gram tissue) 209.0 ± 1.2 220.4 ± 2.1* 323.0 ± 3.20*#
GST (nmol/min/ gram tissue) 163.0 ± 1.1 175.2 ± 2.0* 260.1 ± 3.10*#
GSH (μM) 4.8 ± 0.2 3.1 ± 0.1* 8.7 ± 0.10*#
  1. Group I (non diabetic), group II (diabetic), group III (diabetic treated with curcumin); Values are mean ± SD of 8 rats; TBARS: thiobarbituric acid reactive substances; CAT: catalase; SOD: superoxide dismutase; GST: glutathione-S transferase; GSH: reduced glutathione.
  2. *Mean values are significantly (P < 0.05) different compare to the control (group I). #Mean values are significantly (P < 0.05) different compare to diabetic rats (group II).