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Table 3 Cytotoxicity of Saudi Arabian plants towards sensitive and drug-resistant solid cancer cell lines and normal cells as determined by the resazurin assay

From: Cytotoxicity, mode of action and antibacterial activities of selected Saudi Arabian medicinal plants

Tested samples Sample code Cell lines, IC50(μg/mL ) and degree of resistance*
   MDA-MB-231/pcDNA MDA-MB-231/BCRP HCT116p53 +/+ HCT116p53 -/- U87MG U87MGΔEGFR HepG2 AML 12
Haplophyllum tuberculatum SY177 11.92 26.65 (2.24) 2.42 3.30 (1.36) 15.03 27.67 (1.84) 31.64 -
Pulicaria crispa SY179 14.6 8.37 (0.57) 2.79 2.58 (0.92) 4.31 27.46 (6.37) 27.85 -
Anthemis deserti SY185 - - 24.48 31.94 (1.30) - - - -
Ziziphus nummularia SY188 - - - - - - - -
Neurada procumbens SY189 - - - - 3.01 - - -
Artemisia monosperma SY198 - 26.16 (<0.65) 7.35 6.65 (0.90) 25.25 24.95 (0.99) - -
Ononis serrata SY160 19.28 25.09 (1.30) 14.9 21.94 (1.47) 28.58 31.09 (1.09) - -
Achillea beiberstenii SY-200 10.48 22.32 (2.13) 17.09 17.31 (1.01) - 19.24 (<0.48) 27.28 -
Doxorubicin   1.10 7.83 (7.12) 1.41 4.06 (2.88) 1.06 6.11 (5.76) 1.41 -
  1. (*): The degree of resistance was determined as the ratio of IC50 value of the resistant/IC50 sensitive cell line; (-): >40 μg/mL.