Skip to main content

Table 3 Cytotoxicity of Saudi Arabian plants towards sensitive and drug-resistant solid cancer cell lines and normal cells as determined by the resazurin assay

From: Cytotoxicity, mode of action and antibacterial activities of selected Saudi Arabian medicinal plants

Tested samples

Sample code

Cell lines, IC50(μg/mL ) and degree of resistance*

  

MDA-MB-231/pcDNA

MDA-MB-231/BCRP

HCT116p53 +/+

HCT116p53 -/-

U87MG

U87MGΔEGFR

HepG2

AML 12

Haplophyllum tuberculatum

SY177

11.92

26.65 (2.24)

2.42

3.30 (1.36)

15.03

27.67 (1.84)

31.64

-

Pulicaria crispa

SY179

14.6

8.37 (0.57)

2.79

2.58 (0.92)

4.31

27.46 (6.37)

27.85

-

Anthemis deserti

SY185

-

-

24.48

31.94 (1.30)

-

-

-

-

Ziziphus nummularia

SY188

-

-

-

-

-

-

-

-

Neurada procumbens

SY189

-

-

-

-

3.01

-

-

-

Artemisia monosperma

SY198

-

26.16 (<0.65)

7.35

6.65 (0.90)

25.25

24.95 (0.99)

-

-

Ononis serrata

SY160

19.28

25.09 (1.30)

14.9

21.94 (1.47)

28.58

31.09 (1.09)

-

-

Achillea beiberstenii

SY-200

10.48

22.32 (2.13)

17.09

17.31 (1.01)

-

19.24 (<0.48)

27.28

-

Doxorubicin

 

1.10

7.83 (7.12)

1.41

4.06 (2.88)

1.06

6.11 (5.76)

1.41

-

  1. (*): The degree of resistance was determined as the ratio of IC50 value of the resistant/IC50 sensitive cell line; (-): >40 μg/mL.