Figure 7From: Norartocarpetin from a folk medicine Artocarpus communis plays a melanogenesis inhibitor without cytotoxicity in B16F10 cell and skin irritation in mice The antimelanogenesis mechanism of norartocarpetin. Norartocarpetin decreases cellular melanin production and tyrosinase activity by activating the phosphorylation of JNK and p38 and which results in reducing of MITF protein and p-CREB and inhibiting tyrosinase related protein synthesis including tyrosinase TRP-1 and TRP-2.Back to article page