Norartocarpetin decreases tyrosinase to inhibit α-MSH–induced melanogenesis. Cellular melanin production (A) and downregulation of tyrosinase-related protein expression (B). Data are expressed as mean ± SD of 3 independent experiments. The different superscript letters indicate significant difference at p < 0.05 as analyzed by Student’s t test. *Significantly different from control. #Significantly different from α-MSH–induced melanin production.