Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration

Table 4 Activities of caspase-3, -8 and -9 in MCF-7 cells treated with C. sativum root extract

Treatment	Fold change compared to control
Treatment	Caspase-3	Caspase-8	Caspase-9
Control	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00
*6 h*
200 μg/ml	0.87 ± 0.02	0.83 ± 0.00	0.84 ± 0.03
276 μg/ml	0.86 ± 0.03	0.87 ± 0.03	0.88 ± 0.04
Positive control	0.91 ± 0.01	0.87 ± 0.01	0.87 ± 0.02
*24 h*
200 μg/ml	1.20 ± 0.02*	1.16 ± 0.02*	1.12 ± 0.03*
276 μg/ml	1.28 ± 0.02*	1.21 ± 0.03*	1.30 ± 0.01*
Positive control	1.06 ± 0.01*	1.06 ± 0.02*	1.07 ± 0.02*

The positive controls used were colchicine (caspase-3) and mitomycin C (caspase-8 and -9) at 1 μM.
Values are expressed as fold change compared to control, mean ± SD (n = 3).
*Values are significantly different at P < 0.05 compared to control as tested by the Student’s t-test.

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