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Table 3 Summary of the results of PS exposure apoptosis assay, Caspase-3/7 activity, MMP changes, PARP-1 and Caspase-8 cleavage, full-length Caspase-9 and γH2Ax protein expression in HeLa cells treated with 500 μg/mL concentration of extracts

From: Induction of apoptosis in cancer cell lines by the Red Sea brine pool bacterial extracts

Extract

PS exposure (percentage of stained cells)

Caspase-3/7 activity (fold change)

MMP

PARP-1 cleavage

γH2Ax

Caspase-9 reduction

Caspase-8 cleavage

P3-86A

+ (73.95%)

+ (1.7)

+

+

-

-

+

K30

+ (86.74%)

+ (50.0)

-

-

+

+

-

P3-37B

+ (84.89%)

+ (4.2)

-

+

+

+

+

K18

+ (85.85%)

+ (5.9)

-

+

+

+

+

P3-86B(2)

+ (80.01%)

+ (282.1)

+

+

+

+

+

P3-37C

+ (84.77%)

+ (229.7)

-

+

+

+

+

  1. ‘+’ represents a positive observation, whereas ‘-’represents a negative observation.