PASS-predicted Vitex negundo activity: antioxidant and antiproliferative properties on human hepatoma cells-an in vitro study

Table 2 Part of PASS for VN chemical compounds

	Biological activity
Compound	Lipid peroxidation inhibitor		Antioxidant		Free radical scavengers		Hepatoprotectant		Caspase-3 stimulant		Antiproliferative
	Pa	Pi	Pa	Pi	Pa	P	Pa	Pi	Pa	Pi	Pa	Pi
1	0.813	0.003	0.699	0.004	0.786	0.003	0.717	0.007	0.741	0.009	0.737	0.012
2	0.765	0.004	0.671	0.004	0.765	0.003	0.744	0.006	0.706	0.011	0.754	0.011
3	0.798	0.004	0.749	0,004	0.849	0.002	0.741	0.006	0.778	0.007	0.886	0.005
4	0.711	0.005	0.644	0.004	0.751	0.003	0.658	0.009	0.734	0.009	0.855	0.005
5	0.952	0.002	0.874	0.003	0.973	0.001	0.912	0.002	0.812	0.005	0.817	0.007
6	0.304	0.062	0.788	0.003	0.518	0.009	0.983	0.001	0.679	0.012	0.445	0.005
7	0.415	0.031	0.598	0.005	0.698	0.004	0.986	0.001	0.611	0.006	0.554	0.014
8	0.920	0.002	0.798	0.003	0.956	0.001	0.924	0.002	0.749	0.008	0.715	0.013

Pa—probability “to be active”; Pi—probability “to be inactive”.
(1) 5-hydroxy-7,4′dimethoxy flavones, (2) 5-hydroxy-3,6,7,3′,4′-Pentamethoxy flavones, (3) 5, 3′ dihydroxy-7, 8,4′-trimethoxy flavanone, (4) 5,7-dihydroxy-6,4′dimethoxy flavanone, (5) 7,8-dimethyl herbacetin 3-rhamnoside, (6) Agnuside, (7) Negundoside, (8) Vitegnoside.

ISSN: 2662-7671