Table 2 Changes in the doubling time (g) and specific-growth rates (μ) of the seven candidal species that cultured in the absence (untreated) and presence of Brucea javanica extract
Candida spp. | Doubling time (g) & specific- | Untreated | Brucea javanica L. | ||
|---|---|---|---|---|---|
growth rates (μ) | 1 mg/ml | 3 mg/ml | 6 mg/ml | ||
Candida | g (h) | 2.403 ± 0.095 | 2.461 ± 0.083 | 2.727 ± 0.101 | 3.021 ± 0.094 |
albicans | μ (h-1) | 0.263 ± 0.011 | 0.257 ± 0.008 | 0.130 ± 0.022 | 0.112 ± 0.006 |
Increase in g | - | 1.02-fold | 1.13-fold | 1.26-fold | |
Reduction in μ | - | 2.28% | 50.57% | 57.41% | |
Candida | g (h) | 3.330 ± 0.164 | 2.526 ± 0.124 | 2.096 ± 0.204 | 0.271 ± 0.016 |
dubliniensis | μ (h-1) | 0.251 ± 0.010 | 0.034 ± 0.012 | 0.014 ± 0.003 | 0.002 ± 0.002 |
Increase in g | - | 0.76-fold | 0.63-fold | 0.08-fold | |
Reduction in μ | - | 86.45% | 94.42% | 99.20% | |
Candida | g (h) | 2.229 ± 0.037 | 3.061 ± 0.049 | 2.543 ± 0.041 | 2.843 ± 0.177 |
glabrata | μ (h-1) | 0.263 ± 0.004 | 0.249 ± 0.005 | 0.218 ± 0.004 | 0.025 ± 0.006 |
Increase in g | - | 1.37-fold | 1.14-fold | 1.28-fold | |
Reduction in μ | - | 5.32% | 17.11% | 90.49% | |
Candida | g (h) | 2.542 ± 0.045 | 3.109 ± 0.241 | 1.950 ± 0.096 | 1.024 ± 0.042 |
krusei | μ (h-1) | 0.251 ± 0.006 | 0.030 ± 0.003 | 0.028 ± 0.002 | 0.015 ± 0.002 |
Increase in g | - | 1.22-fold | 0.77-fold | 0.40-fold | |
Reduction in μ | - | 88.05% | 88.84% | 94.02% | |
Candida | g (h) | 2.694 ± 0.058 | 3.425 ± 0.111 | 2.708 ± 0.046 | 0.867 ± 0.043 |
lusitaniae | μ (h-1) | 0.265 ± 0.005 | 0.238 ± 0.003 | 0.087 ± 0.005 | 0.008 ± 0.002 |
Increase in g | - | 1.27-fold | 1.01-fold | 0.32-fold | |
Reduction in μ | - | 10.19% | 67.17% | 96.98% | |
Candida | g (h) | 1.816 ± 0.052 | 1.615 ± 0.108 | 1.554 ± 0.098 | 0.614 ± 0.105 |
parapsilosis | μ (h-1) | 0.141 ± 0.001 | 0.017 ± 0.004 | 0.010 ± 0.002 | 0.003 ± 0.001 |
Increase in g | - | 0.89-fold | 0.86-fold | 0.34-fold | |
Reduction in μ | - | 87.94% | 92.91% | 97.87% | |
Candida | g (h) | 2.809 ± 0.017 | 3.967 ± 0.089 | 3.466 ± 0.108 | 0.568 ± 0.055 |
tropicalis | μ (h-1) | 0.319 ± 0.002 | 0.137 ± 0.003 | 0.026 ± 0.005 | 0.005 ± 0.003 |
Increase in g | - | 1.41-fold | 1.23-fold | 0.20-fold | |
Reduction in μ | - | 57.05% | 91.85% | 98.43% | |