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Table 3 Histopathological scoring of the paracetamol-induced liver injury pre-treated with various doses of MEMM in rats

From: Methanol extract of Melastoma malabathricum leaves exerted antioxidant and liver protective activity in rats

Treatment

Dose (mg/kg)

Steatosis

Necrosis

Inflammation

Haemorrhage

Control

-

-

-

-

-

10% DMSO + Paracetamol

 

-

+++

++

++

Silymarin + Paracetamol

200

-

+

+

+

MEMM + Paracetamol

50

-

++

+

++

250

-

+

+

+

 

500

-

-

+

+

  1. The severity of various features of hepatic injury was evaluated based on those following scoring scheme: - normal, + mild effect, ++ moderate effect, +++ severe effect.