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Table 5 Cytotoxic activity (IC 50 μg/ml) of A. scabra root extracts

From: Cytotoxic effect of Alpinia scabra (Blume) Náves extracts on human breast and ovarian cancer cells

Extracts

Treatment duration (hour)

IC50 a(μg/ml) (SIb)

MCF7

SKOV-3

MRC-5

Methanol

24

70.67 ± 5.86

56.67 ± 1.15

44.98 ± 10.59

48

47.67 ± 4.93

34.67 ± 0.58

47.70 ± 8.68

72

64.00 ± 0.00

34.00 ± 4.36

38.94 ± 5.02

Hexane

24

56.00 ± 2.00

33.33 ± 1.15

30.59 ± 0.36

48

33.67 ± 5.03

28.33 ± 3.51

30.71 ± 3.15

72

40.67 ± 1.15

28.00 ± 1.73

29.59 ± 5.98

Chloroform

24

67. 33 ± 5.03

44.00 ± 5.29

30.27 ± 0.33

48

37.33 ± 4.16

37.00 ± 0.58

51.09 ± 10.80

72

42.67 ± 2.31

33.67 ± 3.21

38.39 ± 5.57

Water

24

>100

>100

>100

48

>100

>100

>100

72

>100

>100

>100

Doxorubicinc

24

2.50 ± 0.10

2.50 ± 0.10

>100

48

2.37 ± 0.23 (32.4)

1.77 ± 0.15 (43.4)

76.87 ± 12.64

72

0.39 ± 0.02 (4.3)

1.47 ± 0.15 (1.1)

1.68 ± 0.42

  1. aData are presented as mean ± SD from three independent experiments triplicate for each. Values in bold characters are considered to have cytotoxic activity (IC5020 μg/ml or less); bSelectivity Index (SI); cPositive control.