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Table 4 Cytotoxic activity (IC 50 μg/ml) of A. scabra rhizome extracts

From: Cytotoxic effect of Alpinia scabra (Blume) Náves extracts on human breast and ovarian cancer cells

Extracts

Treatment duration (hour)

IC50 a(μg/ml) (SIb)

MCF7

SKOV-3

MRC-5

Methanol

24

>100

>100

>100

48

>100

>100

>100

72

>100

>100

>100

Hexane

24

79.67 ± 10.60

40.00 ± 2.00

73.69 ± 2.23

48

60.00 ± 5.66

25.67 ± 0.58

41.31 ± 2.26

72

57.33 ± 1.15

24.00 ± 3.46

53.49 ± 2.71

Chloroform

24

70.67 ± 23.12

21.67 ± 4.73

78.08 ± 7.76

48

39.00 ± 1.41

19.33 ± 0.58 (2.3)

43.56 ± 0.54

72

37.67 ± 0.58

17.33 ± 0.58 (2.6)

44.65 ± 2.57

Water

24

>100

>100

>100

48

>100

>100

>100

72

>100

>100

>100

Doxorubicinc

24

2.50 ± 0.10

2.50 ± 0.10

>100

48

2.37 ± 0.23 (32.4)

1.77 ± 0.15 (43.4)

76.87 ± 12.64

72

0.39 ± 0.02 (4.3)

1.47 ± 0.15 (1.1)

1.68 ± 0.42

  1. aData are presented as mean ± SD from three independent experiments triplicate for each. Values in bold characters are considered to have cytotoxic activity (IC5020 μg/ml or less); bSelectivity Index (SI); cPositive control.