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Table 1 Final body weight, body weight gain, and water consumption of rats treated with different doses of the C. langsdorffii extract and/or DMH and their respective controls, for the comet assay

From: Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon

Treatments (mg/kg)

Final body weight (g)*

Body weight gain (g)*

Water consumption*a

EDTA

166.8 ± 11.6

54.5 ± 7.9

36.9 ± 5.6

DMSO

170.6 ± 11.0

51.1 ± 6.3

41.5 ± 4.7

80

167.5 ± 11.0

54.6 ± 5.8

40.6 ± 7.4

DMH

165.0 ± 11.3

52.6 ± 7.4

37.2 ± 6.5

DMSO + DMH

168.1 ± 10.4

56.6 ± 7.6

44.6 ± 12.3

20 + DMH

167.1 ± 11.4

52.3 ± 9.3

37.9 ± 5.8

40 + DMH

168.1 ± 11.3

49.3 ± 6.3

37.5 ± 6.8

80 + DMH

169.6 ± 10.2

53.3 ± 6.9

45.5 ± 7.2

  1. EDTA, vehicle control; DMH, 1,2-dimethylhydrazine (40 mg/kg); DMSO, dimethylsulfoxide (0.6 g/kg). The numbers 20, 40, and 80 correspond to the extract dose in mg/kg.
  2. *Values are the mean ± standard deviation.
  3. aWater consumption calculated in mL per animal per day.