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Table 4 Effect of turmerone on the concentrations (ng/g tissue) of monoamines and their metabolites in the hypothalamus of mice brain

From: Antidepressant-like activity of turmerone in behavioral despair tests in mice

Group NE MHPG DA DOPAC 5-HT 5-HIAA 5-HIAA/5-HT
Normal 267.4 ± 7.7 201.6 ± 7.8 437.3 ± 13.0 111.0 ± 7.9 345.6 ± 21.8 145.7 ± 13.5 0.44 ± 0.06
Control + FST 207.5 ± 3.2 217.9 ± 8.8 343.6 ± 12.9### 183.4 ± 7.9 216.7 ± 10.4### 238.0 ± 13.8## 0.11 ± 0.05###
Fluoxetine 10 mg/kg + FST 224.7 ± 2.6 202.5 ± 3.1 363.1 ± 3.3 143.1 ± 3.2 422.7 ± 3.3*** 204.6 ± 3.4 0.48 ± 0.10***
Turmerone 2.5 mg/kg + FST 246.1 ± 11.0 166.9 ± 16.4* 555.3 ± 11.4*** 124.2 ± 7.7* 483.0 ± 18.5*** 219.7 ± 14.0 0.45 ± 0.02***
Turmerone 5.0 mg/kg + FST 230.6 ± 13.0 196.2 ± 3.0 436.6 ± 11.6*** 157.3 ± 16.1 539.4 ± 10.5*** 225.4 ± 13.8 0.42 ± 0.02***
  1. Values were the means ± SEM (n = 10). ## p < 0.01, ### p < 0.001 as compared with the normal group. * p < 0.05, *** p < 0.001 as compared with the control + FST group. (One-way ANOVA followed by Scheffe’s test). NE: norepinephrine, MHPG: 3 methoxy-4-hydroxyphenylglycol, DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 5-HT: serotonin, 5-HIAA: 5-hydroxyindoleacetic acid.