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Table 4 Effect of turmerone on the concentrations (ng/g tissue) of monoamines and their metabolites in the hypothalamus of mice brain

From: Antidepressant-like activity of turmerone in behavioral despair tests in mice

Group

NE

MHPG

DA

DOPAC

5-HT

5-HIAA

5-HIAA/5-HT

Normal

267.4 ± 7.7

201.6 ± 7.8

437.3 ± 13.0

111.0 ± 7.9

345.6 ± 21.8

145.7 ± 13.5

0.44 ± 0.06

Control + FST

207.5 ± 3.2

217.9 ± 8.8

343.6 ± 12.9###

183.4 ± 7.9

216.7 ± 10.4###

238.0 ± 13.8##

0.11 ± 0.05###

Fluoxetine 10 mg/kg + FST

224.7 ± 2.6

202.5 ± 3.1

363.1 ± 3.3

143.1 ± 3.2

422.7 ± 3.3***

204.6 ± 3.4

0.48 ± 0.10***

Turmerone 2.5 mg/kg + FST

246.1 ± 11.0

166.9 ± 16.4*

555.3 ± 11.4***

124.2 ± 7.7*

483.0 ± 18.5***

219.7 ± 14.0

0.45 ± 0.02***

Turmerone 5.0 mg/kg + FST

230.6 ± 13.0

196.2 ± 3.0

436.6 ± 11.6***

157.3 ± 16.1

539.4 ± 10.5***

225.4 ± 13.8

0.42 ± 0.02***

  1. Values were the means ± SEM (n = 10). ## p < 0.01, ### p < 0.001 as compared with the normal group. * p < 0.05, *** p < 0.001 as compared with the control + FST group. (One-way ANOVA followed by Scheffe’s test). NE: norepinephrine, MHPG: 3 methoxy-4-hydroxyphenylglycol, DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 5-HT: serotonin, 5-HIAA: 5-hydroxyindoleacetic acid.