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Table 2 Effect of turmerone on the concentrations (ng/g tissue) of monoamines and their metabolites in the striatum of mice brain

From: Antidepressant-like activity of turmerone in behavioral despair tests in mice

Group NE MHPG DA DOPAC 5-HT 5-HIAA 5-HIAA/5-HT
Normal 356.0 ± 9.6 238.0 ± 12.4 526.0 ± 9.2 157.7 ± 14.8 353.3 ± 18.7 214.1 ± 8.5 0.62 ± 0.05
Control + FST 262.3 ± 19.4 261.3 ± 9.6 342.9 ± 8.2### 150.1 ± 7.2 253.9 ± 9.8# 283.0 ± 2.9 1.07 ± 0.08###
Fluoxetine 10 mg/kg + FST 310.4 ± 4.7 236.2 ± 4.8 413.8 ± 5.0 144.6 ± 2.2 599.6 ± 8.8*** 204.7 ± 3.4 0.34 ± 0.01***
Turmerone 2.5 mg/kg + FST 379.1 ± 43.2* 256.4 ± 3.3 933.5 ± 23.1*** 129.7 ± 5.6 852.8 ± 15.3*** 206.4 ± 5.6* 0.26 ± 0.01***
Turmerone 5.0 mg/kg + FST 327.8 ± 12.7 253.3 ± 6.8 776.9 ± 23.8*** 137.5 ± 5.3 731.8 ± 17.6*** 204.2 ± 20.9* 0.28 ± 0.03***
  1. Values were the means ± SEM (n = 10). # p < 0.05, ### p < 0.001 as compared with the normal group. * p < 0.05, ** p < 0.01,*** p <0.001 as compared with the control + FST group. (One-way ANOVA following by Scheffe’s test). NE: norepinephrine, MHPG: 3 methoxy-4-hydroxyphenylglycol, DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 5-HT: serotonin, 5-HIAA: 5-hydroxyindoleacetic acid.