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Table 1 Effect of turmerone on the concentrations (ng/g tissue) of monoamines and their metabolites in the cortex of mice brain

From: Antidepressant-like activity of turmerone in behavioral despair tests in mice

Group NE MHPG DA DOPAC 5-HT 5-HIAA 5-HIAA/5-HT
Normal 402.4 ± 19.8 243.1 ± 6.2 83.5 ± 5.6 72.2 ± 2.7 432.1 ± 22.3 127.2 ± 7.7 0.30 ± 0.03
Control + FST 200.5 ± 23.5### 228.9 ± 15.6 48.1 ± 2.0## 44.6 ± 1.5 326.9 ± 15.5# 255.2 ± 41.8## 0.75 ± 0.14##
Fluoxetine 10 mg/kg + FST 283.4 ± 3.3 180.4 ± 7.6 58.7 ± 1.7 47.4 ± 1.8 600.2 ± 6.1*** 214.3 ± 3.3 0.36 ± 0.01**
Turmerone 2.5 mg/kg + FST 254.9 ± 9.1 172.4 ± 5.2 69.7 ± 6.3 46.9 ± 1.4 734.8 ± 18.6*** 237.0 ± 22.0 0.33 ± 0.03**
Turmerone 5.0 mg/kg + FST 384.2 ± 31.3*** 179.3 ± 5.5* 48.6 ± 8.6 42.5 ± 2.5 629.9 ± 25.5*** 250.2 ± 14.0 0.42 ± 0.02
  1. Values were the means ± SEM (n = 10). # p < 0.05, # # p < 0.01, # # # p < 0.001 as compared with the normal group. ** p < 0.01, *** p < 0.001 as compared with the control + FST group. (One-way ANOVA followed by Scheffe’s test). NE: norepinephrine, MHPG: 3 methoxy-4-hydroxyphenylglycol, DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 5-HT: serotonin, 5-HIAA: 5-hydroxyindoleacetic acid.