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Table 3 Cytotoxicity of the crude extract, fractions and compounds from E. robustum and their selectivity index (SI)

From: Antimicrobial activity and cytotoxicity of the ethanol extract, fractions and eight compounds isolated from Eriosema robustum (Fabaceae)

Samples

Cytotoxicty (LC50, μg/ml)

Selectivity indexa

 

C.a

C.A

A.f

C.n

S.a

P.a

E.f

E.c

Extract and fractions

         

Crude extract

53.45 ± 2.21

0.04

0.04

0.21*

0.08

0.67

0.17

0.67

0.67

Fraction A

17.91 ± 1.71

0.03

0.09*

0.05*

0.01

0.90

0.06

0.45

0.45

Fraction B

93.76 ± 25.62

0.08

0.22*

0.66*

0.66*

0.59

0.30

1.17

1.17

Compounds

         

Robusflavone A (1)

13.20 ± 0.02

0.05

0.20

0.16*

0.05

0.05

0.21

0.05

0.05

Robusflavone B (2)

30.42 ± 3.26

0.24

0.47

0.36*

0.47

0.24

0.48

0.48

0.24

Orostachyscerebroside A (3)

> 100

0.4

0.53*

0.53*

0.4

0.8

1.59

0.8

0.8

Stigmasterol (4)

54.97 ± 11.05

0.44

0.44

0.85

0.44

0.44

0.87

0.22

0.22

1-O-Heptatriacontanoylglycerol (5)

91.52 ± 28.38

0.37

1.41

0.73

0.37

0.73

1.45

0.73

0.73

Eicosanoic acid (6)

NT

-

-

-

-

-

-

-

-

3-O-β-D-Glucopyranoside of sitosterol (7)

>100

0.80

0.80

1.17*

1.17*

0.80

1.58

1.58

0.80

6-Prenylpinocembrin (8)

21.87 ± 0.37

0.17

0.34

0.13*

0.09

0.70

0.35

0.35

0.35

Control

         

Dox

3.32 ± 1.31

        
  1. C.a: Candida albicans (isolate), C.A: Candida albicans (ATCC), A.f: Apergillus fumigatus, C.n: Cryptoccocus neoformans, E.c: Escherichia coli, E.f: Enterococcus faecalis, S.a: Staphylococcus aureus, P.a: s Dox: Doxorubicin with LC50 in μM, NT: not tested, aSI = LC50 /MIC, *SI obtained from average MIC.