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Table 3 Cytotoxicity of the crude extract, fractions and compounds from E. robustum and their selectivity index (SI)

From: Antimicrobial activity and cytotoxicity of the ethanol extract, fractions and eight compounds isolated from Eriosema robustum (Fabaceae)

Samples Cytotoxicty (LC50, μg/ml) Selectivity indexa
  C.a C.A A.f C.n S.a P.a E.f E.c
Extract and fractions          
Crude extract 53.45 ± 2.21 0.04 0.04 0.21* 0.08 0.67 0.17 0.67 0.67
Fraction A 17.91 ± 1.71 0.03 0.09* 0.05* 0.01 0.90 0.06 0.45 0.45
Fraction B 93.76 ± 25.62 0.08 0.22* 0.66* 0.66* 0.59 0.30 1.17 1.17
Compounds          
Robusflavone A (1) 13.20 ± 0.02 0.05 0.20 0.16* 0.05 0.05 0.21 0.05 0.05
Robusflavone B (2) 30.42 ± 3.26 0.24 0.47 0.36* 0.47 0.24 0.48 0.48 0.24
Orostachyscerebroside A (3) > 100 0.4 0.53* 0.53* 0.4 0.8 1.59 0.8 0.8
Stigmasterol (4) 54.97 ± 11.05 0.44 0.44 0.85 0.44 0.44 0.87 0.22 0.22
1-O-Heptatriacontanoylglycerol (5) 91.52 ± 28.38 0.37 1.41 0.73 0.37 0.73 1.45 0.73 0.73
Eicosanoic acid (6) NT - - - - - - - -
3-O-β-D-Glucopyranoside of sitosterol (7) >100 0.80 0.80 1.17* 1.17* 0.80 1.58 1.58 0.80
6-Prenylpinocembrin (8) 21.87 ± 0.37 0.17 0.34 0.13* 0.09 0.70 0.35 0.35 0.35
Control          
Dox 3.32 ± 1.31         
  1. C.a: Candida albicans (isolate), C.A: Candida albicans (ATCC), A.f: Apergillus fumigatus, C.n: Cryptoccocus neoformans, E.c: Escherichia coli, E.f: Enterococcus faecalis, S.a: Staphylococcus aureus, P.a: s Dox: Doxorubicin with LC50 in μM, NT: not tested, aSI = LC50 /MIC, *SI obtained from average MIC.