Figure 1

EA reversed the depressive-like behavior of the stressed rats. The normal group underwent no stress; the Model group received the chronic unpredictable stress (CUS) for 4 weeks; the EA group received CUS for 4 weeks, as well as EA treatment for the latter part of the CUS (2 weeks). (A) The immobility times in the forced swimming test (FST) decreased after 3 and 4 weeks of CUS (1 or 2 weeks of treatment) in the EA group compared with the Model group. (B) The climbing time in the FST was reversed to normal levels by EA treatment. (C) &(D) The percentage of open-arms entries and open-arms time in the elevated plus maze (EPM). The values are presented as the mean ± SE, n = 8 or 18 in each group. Significance of “Model vs Normal” is marked by * (P <0.05) or ** (P <0.01), and that of “EA vs. Model” is marked by # (P <0.05) or ## (P <0.01).