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Table 1 Experimental groups of animals and substances administered

From: Attenuating effect of standardized fruit extract of punica granatum L in rat model of tibial and sural nerve transection induced neuropathic pain

Groups

n

Substance

Description

I

6

Normal control

Only fodder and water.

II

6

Sham control

Tibial and Sural nerve exposed without any transaction.

III

6

TST

TST were performed.

IV

6

Vehicle in TST

CMC 0.5% w/v, p. o. was administered for 24 days daily.

V

6

PFE per se

PFE (300 mg/kg p. o. ones daily) was administered to the normal rats for 24 consecutive days.

VI&VII

6

PFE + TST

PFE (100 and 300 mg/kg p. o. respectively) were administered to the TST rats for 24 consecutive days

VIII

6

BADGE (PPAR-γ antagonist) + TST

BADGE was administered (120 mg/kg IP) to the TST rats for 24 consecutive days.

IX & X

6

BADGE + PFE + TST

BADGE was administered (120 mg/kg IP) before PFE (100 and 300 mg/kg p. o. respectively) administration to the TST rats for 24 consecutive days.

XI

6

L-NAME + TST

L-NAME was administered (5 mg/kg IP) to the TST rats for 24 consecutive days.

XII

6

L-arginine + TST

L-arginine was administered (100 mg/kg IP) to the TST rats for 24 consecutive days.

XIII & XIV

6

L-NAME + PFE + TST

L-NAME was administered (5 mg/kg IP) before PFE (100 and 300 mg/kg p. o. respectively) administration to the TST rats for 24 consecutive days.

XV & XVI

6

L-arginine + PFE + TST

L-arginine was administered (100 mg/kg IP) before PFE (100 and 300 mg/kg p. o. respectively) administration to the TST rats for 24 consecutive days.

XVII

6

Gabapentin per se

Gabapentin (100 mg/kg) p. o. administration to the normal rats for 24 consecutive days.

XVIII

6

Gabapentin + TST

Gabapentin (100 mg/kg) p. o. administration to the TST rats for 24 consecutive days.

  1. TST- Tibial and Sural Nerve Transection; CMC – carboxymethylcellulose; PFE - Punica granatum L Fruit Extract; BADGE- Biphenol-A-diglicydyl ether; p. o.- per os; IP- Intraperitoneal.