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Table 3 Effect of umbelliferone β-D-galactopyranoside on biochemical parameters in STZ-induced diabetic rats

From: Umbelliferone β-D-galactopyranoside from Aegle marmelos (L.) corr. an ethnomedicinal plant with antidiabetic, antihyperlipidemic and antioxidative activity

S. No. Biochemical parameter Normal control Normal control + UFG (40 mg/kg) STZ-diabetic controla STZ diabetes + UFG (10 mg/kg)b STZ diabetes + UFG (20 mg/kg)b STZ diabetes + UFG (40 mg/kg)b STZ diabetes + glibenclamideb
1 Fasting plasma glucose (mg/dL) 91.2 ± 1.114 87.6 ± 1.031 394.2 ± 3.992*** 193.2 ± 1.393** 166.2 ± 2.332*** 123.4 ± 2.379*** 136.4 ± 1.99***
2 Fasting Plasma Insulin (μU/mL) 11.2 ± 0.374 12.2 ± 0.374 2.8 ± 0.383*** 4.4 ± 0.509* 6.8 ± 0.374** 9.4 ± 0.519*** 8.6 ± 0.609***
3 Glycated Heamoglobin (A1c) (%) 1.4 ± 0.141 1.36 ± 0.157 4.82 ± 2.49*** 3.8 ± 0.184* 3.42 ± 0.182** 1.86 ± 0.161*** 2.04 ± 0.212***
4 Hexokinase (μg/mg of tissue) 150.4 ± 3.356 152 ± 3.146 100.8 ± 1.655*** 112.6 ± 1.778** 127.6 ± 1.327** 141.2 ± 1.934*** 139 ± 1.225***
5 Glucose-6-Phosphatase (unit/mg of tissue) 10 ± 0.948 10 ± 1.095 15.4 ± 0.509*** 14.4 ± 0.612ns 12.8 ± 0.374* 10.8 ± 0.583*** 11.6 ± 0.244***
6 Fructose-1-6-biphosphatase (unit/mg of tissue) 30.8 ± 0.861 29.80 ± 0.489 54.6 ± 2.619*** 47.4 ± 1.166* 38.2 ± 1.281** 32.2 ± 0.861*** 34.8 ± 0.583***
7 Total Cholesterol (mg/dL) 66.6 ± 1.503 64.8 ± 1.655 155.8 ± 3.865*** 97.2 ± 1.158** 82.2 ± 2.417** 61.2 ± 2.131*** 66.2 ± 1.463***
8 Triglycerides (mg/dL) 82.4 ± 3.231 80 ± 1.378 154.6 ± 1.161*** 131.8 ± 1.163* 123.2 ± 1.660** 96.2 ± 1.392*** 108.4 ± 1.071***
9 Total HDL Cholesterol (mg/dL) 58.6 ± 1.913 59.8 ± 4.266 30.8 ± 1.319*** 42.8 ± 1.356* 50.4 ± 0.927** 59.2 ± 1.068*** 55.8 ± 1.167***
10 Total LDL Cholesterol (mg/dL) 37.9 ± 1.206 33.4 ± 1.188 197 ± 6.647*** 118.5 ± 1.201** 65.5 ± 1.391*** 44.4 ± 1.668*** 61.8 ± 1.559***
11 Total VLDL Cholesterol (mg/dL) 16.48 ± 0.326 16 ± 0.276 30.92 ± 0.647*** 26.36 ± 0.232* 24.72 ± 0. 331** 19.24 ± 0.279*** 21.68 ± 0.215***
12 Weight Variation (g) ± 196 ± 0.775 197.6 ± 1.288 165.2 ± 3.382*** 190.4 ± 4.686*** 195 ± 3.761*** 203.2 ± 4.428*** 183.4 ± 5.269***
  1. All values represent mean ± SEM * P < 0.05; ** P < 0.01; *** P < 0.001, ns < non significant; ANOVA, followed by Dunnett’s multiple comparison test.
  2. aCompared to vehicle control.
  3. bCompared to diabetic control.