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Table 2 Activity of the HPA on handled rats and non treated TLE rats

From: Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression

Groups ACTH (pg/ml) Corticosterone (pg/ml) Adrenal gland weight (Percentage of body weight) (%)
Handled 0.512 ± 0.114 4126.76 ± 298 0.0076 ± 0.0008
Non treated TLE rats 0.761 ± 0.113* 8267.05 ± 510*** 0.0099 ± 0.0014*
  1. TLE was induced by injecting rats intraperitoneally (i.p.) with pilocarpine (350 mg/kg). Thirty minutes prior to the pilocarpine injection, the animals were treated with atropine (1 mg/ kg, i.p.) to reduce peripheral pilocarpine effects. Results are the mean ± SEM of n = 5 rats per group.
  2. * p < 0.05, significantly different from handling group (Student’s t-test).
  3. *** p < 0.001, significantly different from handling group (Student’s t-test).