Table 1 In vitro antimycobacterial activity of Ursolic acid (UA) and Oleanolic acid (OA) tested by MABA assay
M. tuberculosis strain | MIC (μg mL-1) | ||
|---|---|---|---|
(ATCC) | UA | OA | UA/OA |
H37Rv (27294) | 25 | 50 | 12.5 |
INH-R (35822) | 25 | 25 | 25 |
RIF-R (35838) | 25 | 25 | 25 |
EMB-R (35837) | 25 | 25 | 25 |
STR-R (35820) | 12.5 | 50 | 25 |
DR clinical isolates | |||
MMDO | 25 | 50 | ND |
MTY147 | 25 | 50 | ND |
Non-tuberculous mycobacterium | |||
M. chelonae | 100 | 100 | 100 |
M. avium | 100 | 100 | 100 |
M. smegmatis | >200 | 100 | 100 |
M. fortuitum | 100 | 100 | 100 |
M. simiae | >200 | 100 | 100 |