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Table 1 In vitro activity of C. cajucara (red sacaca) essential oil and its purified 7-hydroxycalamenene-rich fraction against L. chagasi promastigotes and toxicity profile in mouse peritoneal macrophages

From: In vitro cytocidal effects of the essential oil from Croton cajucara (red sacaca) and its major constituent 7- hydroxycalamenene against Leishmania chagasi

Substance tested

L. chagasi

Cytotoxicity [μg/mL]

MIC [μg/mL]

IC50[μg/mL]

Essential oil

250

66.7

>500

7-hydroxycalamenene purified fraction

15.6

1.37

>500

Amphotericin B

0.625

0.01

14.6