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Table 5 Minimal inhibitory concentrations (MICs) of Asarum heterotropoides root constituents against seven beneficial Gram-positive intestinal bacteria using a microtiter plate-based antibacterial bioassay

From: Growth-Inhibiting and morphostructural effects of constituents identified in Asarum heterotropoides root on human intestinal bacteria

  MIC (mg/mL)
Compound Bba Bia Bea Bla Laa Lca Cbb
δ-3-Carene 12.0 cA 5.80 cB 12.0 aA 12.0 aA 12.0 bA 12.0 aA 0.70 eC
Methyleugenol 23.50 aA 23.50 aA 5.80 bC 1.47 cD 12.0 bB 1.47 cD 23.50 aA
1,8-Cineole 23.50 aA 12.0 bB 2.94 cC 2.94 bC 12.0 bB 2.94 bC 12.0 bB
Pellitorine 2.94 eB 5.80 cA 2.94 cB 1.47 cC 2.94 dB 1.47 cC 1.47 dC
(−)-Asarinin 5.80 dA 5.80 cA 5.80 bA 1.47 cC 5.80 cA 1.47 cC 2.94 cB
α-Asarone 12.0 cA 12.0 bA 5.80 bB 1.47 cC 12.0 bA 1.47 cC 12.0 bA
Safrole 22.70 bB 23.50 aA 12.0 aC 12.0 aC 22.70 aB 12.0 aC 23.50 aA
Ciprofloxacin 0.031 fB 0.031 dB 0.031 dB 0.063 dA 0.063 eA 0.063 dA 0.031 fB
  1. Means in a column followed by the same lowercase letter and means in a row followed by the same uppercase letter are not significantly different (P > 0.05; Bonferroni test).
  2. aLactic acid-producing bacteria: Bb, B. bifidum ATCC 29521; Bi, B. infantis ATCC 25962; Be, B. breve ATCC 15700; Bl, B. longum ATCC 15707; La, L. acidophilius ATCC 4356; Lc, L. casei ATCC 393.
  3. bAcidulating bacterium: Cb, C. butyricum ATCC 25779.