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Table 5 Minimal inhibitory concentrations (MICs) of Asarum heterotropoides root constituents against seven beneficial Gram-positive intestinal bacteria using a microtiter plate-based antibacterial bioassay

From: Growth-Inhibiting and morphostructural effects of constituents identified in Asarum heterotropoides root on human intestinal bacteria

 

MIC (mg/mL)

Compound

Bba

Bia

Bea

Bla

Laa

Lca

Cbb

δ-3-Carene

12.0 cA

5.80 cB

12.0 aA

12.0 aA

12.0 bA

12.0 aA

0.70 eC

Methyleugenol

23.50 aA

23.50 aA

5.80 bC

1.47 cD

12.0 bB

1.47 cD

23.50 aA

1,8-Cineole

23.50 aA

12.0 bB

2.94 cC

2.94 bC

12.0 bB

2.94 bC

12.0 bB

Pellitorine

2.94 eB

5.80 cA

2.94 cB

1.47 cC

2.94 dB

1.47 cC

1.47 dC

(−)-Asarinin

5.80 dA

5.80 cA

5.80 bA

1.47 cC

5.80 cA

1.47 cC

2.94 cB

α-Asarone

12.0 cA

12.0 bA

5.80 bB

1.47 cC

12.0 bA

1.47 cC

12.0 bA

Safrole

22.70 bB

23.50 aA

12.0 aC

12.0 aC

22.70 aB

12.0 aC

23.50 aA

Ciprofloxacin

0.031 fB

0.031 dB

0.031 dB

0.063 dA

0.063 eA

0.063 dA

0.031 fB

  1. Means in a column followed by the same lowercase letter and means in a row followed by the same uppercase letter are not significantly different (P > 0.05; Bonferroni test).
  2. aLactic acid-producing bacteria: Bb, B. bifidum ATCC 29521; Bi, B. infantis ATCC 25962; Be, B. breve ATCC 15700; Bl, B. longum ATCC 15707; La, L. acidophilius ATCC 4356; Lc, L. casei ATCC 393.
  3. bAcidulating bacterium: Cb, C. butyricum ATCC 25779.