Figure 4

Effects of SHYGC-containing rabbit sera, prepared with the optimal method, on HBV DNA level in HepG2 2.2.15 cells-conditioned media. Sera containing medium and high doses of SHYGC and ETV alleviated HBV DNA replication (* P < 0.05 and ** P < 0.01 versus Control and Serum Vehicle), and this sort of efficacy of SHYGC was in a dose-dependent fashion (# P < 0.05 versus Low Dose and High Dose). High does SHYGC and ETV exhibited no differential potentials on the down regulation of DNA replication (‡ P < 0.01 versus ETV).