Table 1 Antiproliferative activities of the plant extracts and sinapinic acid on human cancer cell lines
Extracts/Compounds | Molecular weight (Dalton) | Structure | IC50valuesa(mean ± SD; n= 3; mg/mL for the plant extracts; mM for the compounds) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vero cellsb | HeLa cells | HT29 cells | HCT116 cells | MCF-7 cells | Jurkat cells | |||||||||||||||
24 h | 48 h | 72 h | 24 h | 48 h | 72 h | 24 h | 48 h | 72 h | 24 h | 48 h | 72 h | 24 h | 48 h | 72 h | 24 h | 48 h | 72 h | |||
Ethanolic extract | - | - | >3 | >3 | >3 | >3 | 2.6 ± 0.02 | 0.5 ± 0.03 | >3 | >3 | >3 | >3 | >3 | >3 | >3 | >3 | >3 | >3 | >3 | >3 |
Phenolic-rich extract | - | - | >3 | >3 | >3 | 2.20 ± 0.03 | 1.72 ± 0.03 | 0.3 ± 0.05 | >3 | >3 | >3 | >3 | >3 | >3 | >3 | >3 | >3 | >3 | >3 | >3 |
Sinapinic acidc | 224.21 |
| >3 | >3 | >3 | 2.35 ± 0.03 | 2.04 ± 0.06 | 0.9 ± 0.02 | 2.97 ± 0.05 | 2.2 ± 0.03 | 1.6 ± 0.02 | >3 | 2.2 ± 0.15 | 2.1 ± 0.06 | >3 | >3 | >3 | >3 | >3 | 2.8 ± 0.12 |
Sodium butyrated | 110.09 |
| >3 | >3 | >3 | 2.63 ± 0.06 | 2.22 ± 0.13 | 1.2 ± 0.03 | >3 | >3 | 2.57 ± 0.03 | >3 | 2.2 ± 0.20 | 2.0 ± 0.05 | >3 | >3 | >3 | >3 | 2.36 ± 0.19 | 1.5 ± 0.30 |
- aIC50 values represent concentrations of the indicated extracts/compounds that inhibit 50% of cell proliferation.
- bA non cancer cell line.
-
cThe chemical structure of its prototype, a cinnamic acid, is shown here.
. - dA well known HDAC inhibitor.
.