Figure 24

Photomicrographs of histological changes of rat pancreas of isletes of Langerhans: (A) Normal control: normal histological structure of rat pancreas showing normal islet (green arrow) (B) Diabetic control: diabetic control rat showing dilated acini (blue arrow) and focal necrosis (yellow arrow) (C) MM I (100 mg/kg): tested drug rat showing dilated acini (blue arrow) and focal necrosis (yellow arrow) (D) MM II (250 mg/kg): tested drug rat showing and focal necrosis (yellow arrow) (E) MM III (500 mg/kg): tested drug rat showing and focal necrosis (yellow arrow) (F) Glibenclamide (10 mg/kg): glibenclamide treated rat pancreas showing normal islet (green arrow). For each group 6 rats were examined and 50 pictures were taken. The above picture for each group was chosen randomly from the 80 pictures in this group. Original magnification, 10 ×.