Table 2 The pharmacological effects of Berberis vulgaris (NAPALERT; natural products alert database)
System | Effect | Part of plant | Preparation |
|---|---|---|---|
Cardiovascular | Hypotensive activity | Dried root | Alkaloid fraction |
Dried fruit | Aqueous extract | ||
Gastrointestinal | Gastric secretory stimulation | Root | Ethanol—H20 (67%) extract |
Endocrine | Choleretic activity in rat | Dried root | Total alkaloids |
Choleretic activity | Stem bark | ||
Increases tone of the digestive tract and gives rise to increased and irregular peristalsis | Dried root | ||
Anticholinergic activity in guinea pig ileum | Dried fruit | Decoction | |
Menstruation induction effect in guinea pig | Stem | Ethanol (95%) extract | |
Uterine stimulant effect in cat, rabbit and guinea-pig | Leaf | Ethanol-acetone (50%) extract | |
Immune system | Antibody formation suppression in mouse | Dried root | Alkaloid fraction |
Antiinflammatory activity | Root | Alkaloid fraction | |
Organisms | Complement alternative pathway inhibition | Root | Ethanol (l00%) extract |
Delayed type cutaneous hypersensitivity inhibition | Alkaloid fraction and ethanol (95%) extract Alkaloid fraction | ||
Central nervous system | Antipyretic activity in rat | Dried bark | Alkaloid fraction |
Dried fruit | Ethanol (95%) extract | ||
Narcotic antagonist activity | Dried root | ||
Sedative | Fruit | ||
Renal | Diuretic activity in rat | Dried bark | Alkaloid fraction |
Other | Toxicity assessment in mouse — LD50 = 520 0 mg/kg | Dried root | Alkaloid fraction |
Toxicity assessment in mouse — LD50 = 2.6 ± 022 g/kg b w | |||
Male reproduction | Idiopathic ma factors due to oxidative damage | Root | Crude methanolic (95%) extraction |
Crude acetic acid (5%) extraction |