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Table 2 The pharmacological effects of Berberis vulgaris (NAPALERT; natural products alert database)

From: In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects

System Effect Part of plant Preparation
Cardiovascular Hypotensive activity Dried root Alkaloid fraction
Dried fruit Aqueous extract
Gastrointestinal Gastric secretory stimulation Root Ethanol—H20 (67%) extract
Endocrine Choleretic activity in rat Dried root Total alkaloids
Choleretic activity Stem bark
Increases tone of the digestive tract and gives rise to increased and irregular peristalsis Dried root
Anticholinergic activity in guinea pig ileum Dried fruit Decoction
Menstruation induction effect in guinea pig Stem Ethanol (95%) extract
Uterine stimulant effect in cat, rabbit and guinea-pig Leaf Ethanol-acetone (50%) extract
Immune system Antibody formation suppression in mouse Dried root Alkaloid fraction
Antiinflammatory activity Root Alkaloid fraction
Organisms Complement alternative pathway inhibition Root Ethanol (l00%) extract
Delayed type cutaneous hypersensitivity inhibition Alkaloid fraction and ethanol (95%) extract Alkaloid fraction
Central nervous system Antipyretic activity in rat Dried bark Alkaloid fraction
Dried fruit Ethanol (95%) extract
Narcotic antagonist activity Dried root  
Sedative Fruit  
Renal Diuretic activity in rat Dried bark Alkaloid fraction
Other Toxicity assessment in mouse — LD50 = 520 0 mg/kg Dried root Alkaloid fraction
Toxicity assessment in mouse — LD50 = 2.6 ± 022 g/kg b w
Male reproduction Idiopathic ma factors due to oxidative damage Root Crude methanolic (95%) extraction
   Crude acetic acid (5%) extraction