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Figure 1 | BMC Complementary and Alternative Medicine

Figure 1

From: Targeting beta-Catenin signaling to induce apoptosis in human breast cancer cells by z-Guggulsterone and Gugulipid extract of Ayurvedic medicine plant Commiphora mukul

Figure 1

A, Effect of GL (GL contains ~3.75% z-Gug and was standardized to z-Gug (μM)) on survival of MCF-7 and MDA-MB-231 (A) cells determined by the colonogenic survival assay. Cells were treated with different concentrations of GL for 24 h. Columns, mean of three determinations; bars, SE. *Significantly different (P<0.05) compared with DMSO-treated control by one-way ANOVA followed by Dunnett’s test. Similar results were observed in two independent experiments. Representative data from a single experiment are shown. Effect of GL (B and D) and z-Gug (C) on survival of MCF-7, MDA-MB-231 and HMEC cells determined by the trypan blue dye exclusion assay. Cells were treated with different concentrations of GL or z-Gug for 24 h. Columns, mean of three determinations; bars, SE. *Significantly different (P<0.05) compared with DMSO-treated control by one-way ANOVA followed by Dunnett’s test. Similar results were observed in two independent experiments. Representative data from a single experiment are shown.

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