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Table 1 Anti-inflammatory effect of the aqueous-methanol extract of P. verticillatum Rhizomes (PR) in carrageenan-induced hind paw edema in rats

From: Studies on tracheorelaxant and anti-inflammatory activities of rhizomes of Polygonatum verticillatum

Group

Dose mg/kg

Increase in paw volume (Mean ± SEM) in mL

1 h

2 h

3 h

4 h

5 h

Saline

10

0.70 ± 0.031

0.69 ± 0.040

0.69 ± 0.049

0.70 ± 0.067

0.72 ± 0.053

PR

50

0.64 ± 0.045 (08.57%)

0.61 ± 0.054 (11.59%)

0.55 ± 0.049 (20.29%)

0.54 ± 0.053 (22.85%)

0.55 ± 0.049 (23.61%)

 

100

0.56 ± 0.036 (20.00%)

0.50 ± 0.049* (27.53%)

0.37 ± 0.058** (46.37%)

0.39 ± 0.062** (44.29%)

0.47 ± 0.062* (34.72%)

 

200

0.47 ± 0.040* (32.86%)

0.35 ± 0.067** (49.27%)

0.24 ± 0.045** (65.22%)

0.31 ± 0.053** (55.71%)

0.34 ± 0.062** (52.78%)

Aspirin

100

0.23 ± 0.040** (67.14%)

0.19 ± 0.017** (72.46%)

0.17 ± 0.031** (78.1%)

0.18 ± 0.022** (75.71%)

0.18 ± 0.036** (75.00%)

  1. Experimental data are expressed as mean ± S.E.M. for group of at least six animals. One- way ANOVA was utilized as judgment test of significant differences among groups followed by Dunnett’s multiple comparison post-test. A probability of * P < 0.05 or **P < 0.01 was considered significant from control. Protection (%) is shown in parenthesis.