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Table 8 Serum biochemical findings in rats Wistar treated with Dioscorea villosa at a single dose (5 g/kg)

From: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

Parameters FC FT R1 Female MC MT R1 Male
Albumin (g/dL) 3.06 ± 0.097 3.06 ± 0.030 2.6 – 3.4 a 3.03 ± 0.112 2.73 ± 0.042* 2.7 – 3.2 a
ALP (U/L) 48.00 ± 4.669 73.43 ± 5.622** 63 – 138 a 80.00 ± 4.889 109.4 ± 6.575** 79 – 196 a
TGP or ALT (U/L) 40.60 ± 3.614 51.57 ± 2.999* 26 – 60 a 68.43 ± 7.234 62.43 ± 2.653 36 – 58 a
TGO or AST (U/L) 106.80 ± 8.509 86.00 ± 5.499 83 – 184 a 160.9 ± 15.33 121.1 ± 14.12 81 – 180 a
Creatinine (mg/dL) 0.49 ± 0.007 0.5329 ± 0.015 0.4 – 0.7 a 0.59 ± 0.019 0.51 ± 0.007** 0.44 – 0.64 a
GLUC (mg/dL) 131.40 ± 7.593 161.7 ± 5.222** 61 - 147 a 157.6 ± 7.030 172.7 ± 7.819 79 – 144 a
K+ (mmol/L) 4.05 ± 0.193 4.06 ± 0.146 3.7 – 5.7 a 5.814 ± 0.370 5.07 ± 0.185 4.2 – 6.4 a
Na+ (mmol/L) 133.40 ± 0.812 134.10 ± 0.459 132 – 146 a 135.6 ± 1.478 135.3 ± 0.356 135 – 144 a
Total Protein (g/dL) 4.17 ± 0.063 4.27 ± 0.052 6.1 – 7.4 a 4.614 ± 0.230 3.81 ± 0.103** 5.4 – 6.6 a
TRIG (mg/dL) 32.75 ± 2.136 42.57 ± 3.683 39 – 130 a 46.57 ± 3.077 54.57 ± 6.294 42 – 160 a
Urea (mg/dL) 33.60 ± 1.503 37.14 ± 1.668 30 – 57 a 47.43 ± 1.251 37.57 ± 1.232 30 – 42 a
Uric acid (mg/dL) 1.65 ± 0.132 2.04 ± 0.169 1.2 – 2.5 a 3.37 ± 0.377 2.41 ± 0.298 0.9 – 2.0 a
Bil.IND (mg/dL) 0.08 ± 0.004 0.08 ± 0.003 0.01 – 0.01 a 0.07 ± 0.011 0.08 ± 0.003 0.01 – 0.01 a
D.Bil (mg/dL) 0.02 ± 0.004 0.02 ± 0.003 0.01 – 0.03 a 0.03 ± 0.011 0.02 ± 0.003 0.01 – 0.03 a
TBil (mg/dL) 0.10 ± 0.004 0.10 ± 0.003 0.07 – 0.09 a 0.10 ± 0.010 0.10 ± 0.003 0.07 – 0.09 a
CHOL (mg/dL) 60.60 ± 2.315 56.57 ± 2.599 55 – 79 a 59.57 ± 3.191 50.14 ± 2.405 46 – 101 a
  1. FC (control female), FT (treated female), MC (control male), MT (treated male). N = 10. Data are expressed as mean ± S.D. * Indicate statistical difference between the control and treated group *p < 0.05, **p < 0.01 and ***p < 0.001 (test t). R1 (reference female); R2 (reference male); a Melo (2012).