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Table 8 Serum biochemical findings in rats Wistar treated with Dioscorea villosa at a single dose (5 g/kg)

From: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

Parameters

FC

FT

R1 Female

MC

MT

R1 Male

Albumin (g/dL)

3.06 ± 0.097

3.06 ± 0.030

2.6 – 3.4 a

3.03 ± 0.112

2.73 ± 0.042*

2.7 – 3.2 a

ALP (U/L)

48.00 ± 4.669

73.43 ± 5.622**

63 – 138 a

80.00 ± 4.889

109.4 ± 6.575**

79 – 196 a

TGP or ALT (U/L)

40.60 ± 3.614

51.57 ± 2.999*

26 – 60 a

68.43 ± 7.234

62.43 ± 2.653

36 – 58 a

TGO or AST (U/L)

106.80 ± 8.509

86.00 ± 5.499

83 – 184 a

160.9 ± 15.33

121.1 ± 14.12

81 – 180 a

Creatinine (mg/dL)

0.49 ± 0.007

0.5329 ± 0.015

0.4 – 0.7 a

0.59 ± 0.019

0.51 ± 0.007**

0.44 – 0.64 a

GLUC (mg/dL)

131.40 ± 7.593

161.7 ± 5.222**

61 - 147 a

157.6 ± 7.030

172.7 ± 7.819

79 – 144 a

K+ (mmol/L)

4.05 ± 0.193

4.06 ± 0.146

3.7 – 5.7 a

5.814 ± 0.370

5.07 ± 0.185

4.2 – 6.4 a

Na+ (mmol/L)

133.40 ± 0.812

134.10 ± 0.459

132 – 146 a

135.6 ± 1.478

135.3 ± 0.356

135 – 144 a

Total Protein (g/dL)

4.17 ± 0.063

4.27 ± 0.052

6.1 – 7.4 a

4.614 ± 0.230

3.81 ± 0.103**

5.4 – 6.6 a

TRIG (mg/dL)

32.75 ± 2.136

42.57 ± 3.683

39 – 130 a

46.57 ± 3.077

54.57 ± 6.294

42 – 160 a

Urea (mg/dL)

33.60 ± 1.503

37.14 ± 1.668

30 – 57 a

47.43 ± 1.251

37.57 ± 1.232

30 – 42 a

Uric acid (mg/dL)

1.65 ± 0.132

2.04 ± 0.169

1.2 – 2.5 a

3.37 ± 0.377

2.41 ± 0.298

0.9 – 2.0 a

Bil.IND (mg/dL)

0.08 ± 0.004

0.08 ± 0.003

0.01 – 0.01 a

0.07 ± 0.011

0.08 ± 0.003

0.01 – 0.01 a

D.Bil (mg/dL)

0.02 ± 0.004

0.02 ± 0.003

0.01 – 0.03 a

0.03 ± 0.011

0.02 ± 0.003

0.01 – 0.03 a

TBil (mg/dL)

0.10 ± 0.004

0.10 ± 0.003

0.07 – 0.09 a

0.10 ± 0.010

0.10 ± 0.003

0.07 – 0.09 a

CHOL (mg/dL)

60.60 ± 2.315

56.57 ± 2.599

55 – 79 a

59.57 ± 3.191

50.14 ± 2.405

46 – 101 a

  1. FC (control female), FT (treated female), MC (control male), MT (treated male). N = 10. Data are expressed as mean ± S.D. * Indicate statistical difference between the control and treated group *p < 0.05, **p < 0.01 and ***p < 0.001 (test t). R1 (reference female); R2 (reference male); a Melo (2012).