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Table 6 Effect of Dioscorea villosa after oral administration (30 days) on hematologic parameters interaction in Wistar rats ( n= 10)

From: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

Parameters

FC

FT

R1 Female

MC

MT

R1 Male

Leukocyte (×103/mm3)

5.28 ± 0.896

7.16 ± 1.604

4.7 – 12.98a

8.20 ± 1.959

8.37 ± 1.376

5.7 – 13.9 a

Erythrocytes (×106/mm3)

8.15 ± 0.262

8.76 ± 0.421

7.3 – 8.64 a

9.40 ± 0.339

9.62 ± 0.303

6.7 – 8.6 a

Hemoglobin (g/dl)

14.38 ± 0.473

15.17 ± 0.566

13.2 – 15.1 a

15.65 ± 0.602

16.33 ± 0.409*

12.8 – 15.9 a

Hematocrit (%)

40.34 ± 1.571

42.11 ± 1.515

39.1 – 48.5 a

42.53 ± 1.497

44.50 ± 0.818**

39.1 – 48.7 a

VCM (fl)

49.49 ± 0.737

48.27 ± 1.250

49.1 – 62.5 a

45.24 ± 0.964

46.33 ± 1.029*

50.0 – 59.0 a

HCM (pg)

17.63 ± 0.149

17.28 ± 0.405

16.6 – 18.9 a

16.64 ± 0.236

17.0 ± 0.252**

17.0 – 19.5a

CHCM (g/dl)

35.65 ± 0.299

35.82 ± 0.323

29.9 – 34.9 a

36.80 ± 0.573

36.70 ± 0.472

30.5 – 35.3 a

Platelets (×106/mm3)

1115.30 ± 115.039

1356.30 ± 90.371***

757 – 1476 a

1111.20 ± 135.711

1183.89 ± 66.196

837 – 1455 a

Neutrophil (%)

36.64 ± 2.587

24.35 ± 4.461***

5.4 – 37.5 a

41.80 ± 4.007

30.32 ± 5.052***

17.1 – 47.9 a

Lymphocyte (%)

58.49 ± 3.222

71.59 ± 4.228***

57.9 – 90.0 a

51.43 ± 3.969

64.18 ± 5.332***

48.7 – 78.1 a

Monocyte (%)

4.42 ± 0.947

3.90 ± 0.587

0.6 – 7.9 a

6.12 ± 1.353

4.70 ± 1.983

1.0 – 6.5 a

Eosinophil (%)

0.45 ± 0.534

0.16 ± 0.101

0.2 – 4.5 a

0.65 ± 0.701

0.23 ± 0.150

0.3 – 4.0 a

  1. FC (control female), FT (treated female), MC (control male), MT (treated male). N = 10. Data are expressed as mean ± S.D. * Indicate statistical difference between the control and treated group *p < 0.05, **p < 0.01 and ***p < 0.001 (test t). R1 (reference female); R2 (reference male); a Melo (2012).