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Table 6 Effect of Dioscorea villosa after oral administration (30 days) on hematologic parameters interaction in Wistar rats ( n= 10)

From: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

Parameters FC FT R1 Female MC MT R1 Male
Leukocyte (×103/mm3) 5.28 ± 0.896 7.16 ± 1.604 4.7 – 12.98a 8.20 ± 1.959 8.37 ± 1.376 5.7 – 13.9 a
Erythrocytes (×106/mm3) 8.15 ± 0.262 8.76 ± 0.421 7.3 – 8.64 a 9.40 ± 0.339 9.62 ± 0.303 6.7 – 8.6 a
Hemoglobin (g/dl) 14.38 ± 0.473 15.17 ± 0.566 13.2 – 15.1 a 15.65 ± 0.602 16.33 ± 0.409* 12.8 – 15.9 a
Hematocrit (%) 40.34 ± 1.571 42.11 ± 1.515 39.1 – 48.5 a 42.53 ± 1.497 44.50 ± 0.818** 39.1 – 48.7 a
VCM (fl) 49.49 ± 0.737 48.27 ± 1.250 49.1 – 62.5 a 45.24 ± 0.964 46.33 ± 1.029* 50.0 – 59.0 a
HCM (pg) 17.63 ± 0.149 17.28 ± 0.405 16.6 – 18.9 a 16.64 ± 0.236 17.0 ± 0.252** 17.0 – 19.5a
CHCM (g/dl) 35.65 ± 0.299 35.82 ± 0.323 29.9 – 34.9 a 36.80 ± 0.573 36.70 ± 0.472 30.5 – 35.3 a
Platelets (×106/mm3) 1115.30 ± 115.039 1356.30 ± 90.371*** 757 – 1476 a 1111.20 ± 135.711 1183.89 ± 66.196 837 – 1455 a
Neutrophil (%) 36.64 ± 2.587 24.35 ± 4.461*** 5.4 – 37.5 a 41.80 ± 4.007 30.32 ± 5.052*** 17.1 – 47.9 a
Lymphocyte (%) 58.49 ± 3.222 71.59 ± 4.228*** 57.9 – 90.0 a 51.43 ± 3.969 64.18 ± 5.332*** 48.7 – 78.1 a
Monocyte (%) 4.42 ± 0.947 3.90 ± 0.587 0.6 – 7.9 a 6.12 ± 1.353 4.70 ± 1.983 1.0 – 6.5 a
Eosinophil (%) 0.45 ± 0.534 0.16 ± 0.101 0.2 – 4.5 a 0.65 ± 0.701 0.23 ± 0.150 0.3 – 4.0 a
  1. FC (control female), FT (treated female), MC (control male), MT (treated male). N = 10. Data are expressed as mean ± S.D. * Indicate statistical difference between the control and treated group *p < 0.05, **p < 0.01 and ***p < 0.001 (test t). R1 (reference female); R2 (reference male); a Melo (2012).