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Table 5 Effect of Dioscorea villosa after oral administration (single dose-5 g/Kg) on hematologic parameters considering sex interaction in Wistar rats ( n= 6)

From: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

    Groups

Parameters

FC

FT

R1

MC

MT

R2

Leukocyte (×103/mm3)

5.17 ± 0.853

7.18 ± 0.385

4.7 – 12.98 a

7.03 ± 0.677

7.70 ± 1.220

5.7 – 13.9 a

Erythrocytes (×106/mm3)

7.89 ± 0.395

8.60 ± 0.135

7.3 – 8.64 a

9.56 ± 0.249

9.66 ± 0.230

6.7 – 8.6a

Hemoglobin (g/dl)

13.43 ± 0.685

14.87 ± 0.225

13.2 – 15.1 a

15.59 ± 0.417

15.91 ± 0.309

12.8 – 15.9 a

Hematocrit (%)

42.93 ± 2.166

43.37 ± 0.569

39.1 – 48.5 a

48.43 ± 1.206

45.60 ± 0.649

39.1 – 48.7 a

VCM (fl)

54.40 ± 0.727

49.87 ± 0.201***

49.1 – 62.5 a

50.70 ± 0.439

47.21 ± 0.472***

50 – 59 a

HCM (pg)

17.00 ± 0.089

17.08 ± 0.065

16.6 – 18.9 a

16.31 ± 0.112

16.5 ± 0.104

17.0 – 19.5 a

CHCM (g/dl)

31.28 ± 0.433

34.27 ± 0.071***

29.9 – 34.9 a

32.17 ± 0.191

34.91 ± 0.265***

30.5 – 35.3 a

Platelets (×106/mm3)

1070 ± 74.760

1246 ± 59.830

757 – 1476 a

1198 ± 41.10

1141 ± 73.77

837 – 1455 a

Neutrophil (%)

48.40 ± 7.259

36.97 ± 2.070

5.4 – 37.5 a

45.84 ± 1.335

48.80 ± 3.384

17.1 – 47.9 a

Lymphocyte (%)

47.46 ± 5.432

57.73 ± 2.464

57.9 – 90.0 a

48.26 ± 1.716

46.09 ± 2.773

48.7 – 78.1 a

Monocyte (%)

2.857 ± 0.739

3.43 ± 0.814

0.6 – 7.9 a

3.47 ± 0.201

3.63 ± 0.432

1.0 – 6.5 a

Eosinophil (%)

1.60 ± 0.323

1.30 ± 0.206

0.2 – 4.5 a

0.16 ± 0.031

0.08 ± 0.016

0.3 – 4.0 a

  1. FC (control female), FT (treated female), MC (control male), MT (treated male). N = 06. Data are expressed as mean ± S.D. * Indicate statistical difference between the control and treated group *p < 0.05, **p < 0.01 and ***p < 0.001 (test t). R1 (reference female); R2 (reference male); a Melo (2012).