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Table 5 Effect of Dioscorea villosa after oral administration (single dose-5 g/Kg) on hematologic parameters considering sex interaction in Wistar rats ( n= 6)

From: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

    Groups
Parameters FC FT R1 MC MT R2
Leukocyte (×103/mm3) 5.17 ± 0.853 7.18 ± 0.385 4.7 – 12.98 a 7.03 ± 0.677 7.70 ± 1.220 5.7 – 13.9 a
Erythrocytes (×106/mm3) 7.89 ± 0.395 8.60 ± 0.135 7.3 – 8.64 a 9.56 ± 0.249 9.66 ± 0.230 6.7 – 8.6a
Hemoglobin (g/dl) 13.43 ± 0.685 14.87 ± 0.225 13.2 – 15.1 a 15.59 ± 0.417 15.91 ± 0.309 12.8 – 15.9 a
Hematocrit (%) 42.93 ± 2.166 43.37 ± 0.569 39.1 – 48.5 a 48.43 ± 1.206 45.60 ± 0.649 39.1 – 48.7 a
VCM (fl) 54.40 ± 0.727 49.87 ± 0.201*** 49.1 – 62.5 a 50.70 ± 0.439 47.21 ± 0.472*** 50 – 59 a
HCM (pg) 17.00 ± 0.089 17.08 ± 0.065 16.6 – 18.9 a 16.31 ± 0.112 16.5 ± 0.104 17.0 – 19.5 a
CHCM (g/dl) 31.28 ± 0.433 34.27 ± 0.071*** 29.9 – 34.9 a 32.17 ± 0.191 34.91 ± 0.265*** 30.5 – 35.3 a
Platelets (×106/mm3) 1070 ± 74.760 1246 ± 59.830 757 – 1476 a 1198 ± 41.10 1141 ± 73.77 837 – 1455 a
Neutrophil (%) 48.40 ± 7.259 36.97 ± 2.070 5.4 – 37.5 a 45.84 ± 1.335 48.80 ± 3.384 17.1 – 47.9 a
Lymphocyte (%) 47.46 ± 5.432 57.73 ± 2.464 57.9 – 90.0 a 48.26 ± 1.716 46.09 ± 2.773 48.7 – 78.1 a
Monocyte (%) 2.857 ± 0.739 3.43 ± 0.814 0.6 – 7.9 a 3.47 ± 0.201 3.63 ± 0.432 1.0 – 6.5 a
Eosinophil (%) 1.60 ± 0.323 1.30 ± 0.206 0.2 – 4.5 a 0.16 ± 0.031 0.08 ± 0.016 0.3 – 4.0 a
  1. FC (control female), FT (treated female), MC (control male), MT (treated male). N = 06. Data are expressed as mean ± S.D. * Indicate statistical difference between the control and treated group *p < 0.05, **p < 0.01 and ***p < 0.001 (test t). R1 (reference female); R2 (reference male); a Melo (2012).