Antileptospiral activity of xanthones from Garcinia mangostanaand synergy of gamma-mangostin with penicillin G

Table 2 Susceptibility of Leptospira serovars to penicillin G, γ-Mangostin and the combination of both compounds

Leptospiral serovar	MIC (μg/ml)				FIC* index	Antileptospiral effect
	Before combination		After combination
	Penicillin G	γ-Mangostin	Penicillin G	γ-Mangostin
Patoc	6.25	200	3.13	50	0.75	No interaction
Autumnalis	3.13	≥800	1.56	≤1.56	0.50	Synergy
Bataviae	1.56	100	0.78	≤1.56	0.52	Synergy
Javanica	0.39	100	≤0.01	≤1.56	0.04	Synergy
Saigon	0.78	100	3.13	≤1.56	4.03	Antagonism

*FIC index = FIC_pencillin + FIC_γ-mangostin = [Pencillin]/MIC_penicillin + [γ-mangostin]/MIC_γ-mangostin; Synergy; <=0.5, No interaction; >0.5 - 4; Antagonism > 4.

ISSN: 2662-7671