Effects of traditional Chinese medicine Xin-Ji-Er-Kang formula on 2K1C hypertensive rats: role of oxidative stress and endothelial dysfunction

Table 3 Effect of XJEKs on aorta remodeling in 2K1C rats (mean ± SD, n = 8 ~ 11)

Group	TAA (×10³um²)	LA (×10³um²)	CSA (×10³um²)	CSA/TAA (%)	AR (um)	Lumen (um)	Media (um)	Media/lumen (%)
Sh-Op	2671.83 ± 108.18	2354.67 ± 99.27	317.17 ± 56.36	11.86 ± 1.99	374.58 ± 16.07	339.72 ± 18.89	34.86 ± 4.85	10.33 ± 1.90
Model	2819.57 ± 82.65^**	2454.29 ± 71.59^*	365.29 ± 86.36	12.92 ± 2.81	405.23 ± 13.43^**	357.43 ± 12.14^*	47.80 ± 5.27^**	13.39 ± 1.52^**
XJEK
6 g/kg	2854.00 ± 162.03	2505.29 ± 176.62	348.71 ± 35.81	12.27 ± 1.66	408.76 ± 20.55	364.43 ± 24.35	44.32 ± 4.79	12.27 ± 2.10
12 g/kg	2764.00 ± 185.83	2411.33 ± 250.26	352.67 ± 66.40	12.90 ± 3.13	400.35 ± 26.12	354.46 ± 29.84	45.89 ± 4.95	13.06 ± 2.31
24 g/kg	2694.33 ± 82.08^##	2379.67 ± 65.31^#	314.67 ± 45.65^#	11.66 ± 1.52	383.59 ± 11.80^##	347.32 ± 16.20	36.27 ± 11.11^##	10.54 ± 3.54^#
Fosinopril
15 mg/kg	2692.13 ± 77.46^##	2410.13 ± 111.76	282.00 ± 56.86^##	10.50 ± 2.28^#	384.36 ± 26.74^#	347.05 ± 33.86	37.30 ± 13.02^#	11.11 ± 4.93

TAA area of total aorta, LA area of lumen, CSA cross-sectional area, AR aorta radius. The vascular remodeling of the upper thoracic aorta exposed to 2K1C was observed at the end of 4^th week, which could be prevented by treatment with XJEK at all doses for 4 weeks, as well as the positive drug fosinopril. ^* P < 0.05, ^** P < 0.01 vs Sh-Op group; ^# P < 0.05, ^## P < 0.01 vs model group.

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