Inhibition of UVA-induced upregulation of tyrosinase mRNA (A and B) and downregulation of γ-GCLC and γ-GCLM (C and D) as well as GST (E and F) by AVS073 and GA. The data shown as the fold change in gene expression normalized to GAPDH and relative to the control sample. Values given are mean±SEM. The statistical significance of differences between the control and UVA-irradiated cells was determined by Student’s t test and between UVA-irradiated and AVS073 extracts- or GA-treated cells by one-way ANOVA followed by Tukey’s post hoc test. *p < 0.05; **p < 0.01; ***p < 0.001 compared with AVS073- or GA-treated cells without UV irradiation.