The flavonoid content and antiproliferative, hypoglycaemic, anti-inflammatory and free radical scavenging activities of Annona dioica St. Hill

Table 2 GI ₅₀ , TGI and LC ₅₀ (μg/mL) for EAD and Dox

	EAD			Dox
Cancer cell lines	GI₅₀	TGI	LC₅₀	GI₅₀	TGI	LC₅₀
U251 (glioma)	83.47			5.07	23.45
UACC-62 (melanoma)	> 100			0.06	0.86
MCF7 (breast)	11.10	> 100		0.14	24.52
NCI/ADR-RES (ovarian resistance)	1.95			1.74	23.92
786-0 (renal)	> 100			0.22	1.51
NCI-H460 (lung)	0.03	> 100		0.05
OVCAR-3 (ovarian)	6.38			0.30	1.72
HT29 (colon)	0.10	4.10	> 100	2.12	7.31	20.86
K-562 (leukemia)	31.13			0.90
Vero				1.40	11.36

EAD (crude methanol extract); dox (doxorubicin); GI₅₀ (growth inhibitory activity); TGI (cytostatic activity); LC₅₀ (cytotoxic activity); IC₅₀ >100 (μg/mL) was considered not active.

ISSN: 2662-7671