| |
EC50(M), REP
|
|---|
|
Cell-line
|
E2
|
Rhodoeosein
|
Emodin
|
Genistein
|
|---|
|
BG1Luc4E2
|
1.8 × 10-11, 1
|
1.2 × 10-4, 3.5 × 10-7
|
1.3 × 10-6, 1.5 × 10-5
|
7.3 × 10-7, 2.5 × 10-5
|
|
SKBR3 (ERα)
|
2.0 × 10-11, 1
|
5.8 × 10-6, 4.0 × 10-6
|
1.3 × 10-6, 1.5 × 10-5
|
9.0 × 10-7, 2.2 × 10-5
|
|
SKBR3 (ERβ)
|
2.7 × 10-10, 1
|
1.8 × 10-5, 1.8 × 10-5
|
3.0 × 10-6, 8.9 × 10-5
|
8.3 × 10-8, 3.3 × 10-3
|
- Comparison of concentration for half-maximal induction (EC50) and relative estrogenic potency (REP) for E2, rhodoeosein, and emodin in human carcinoma cell-lines BG1Luc4E2 (ovarian) and SKBR3 (breast) transfected with either ERα or ERβ. Data for genistein is included for comparative purposes. REP = EC50 E2/EC50 chemical.
