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Table 2 Potency comparisons of phytoestrogens

From: 2,3-cis-2R,3R-(−)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines

  EC50(M), REP
Cell-line E2 Rhodoeosein Emodin Genistein
BG1Luc4E2 1.8 × 10-11, 1 1.2 × 10-4, 3.5 × 10-7 1.3 × 10-6, 1.5 × 10-5 7.3 × 10-7, 2.5 × 10-5
SKBR3 (ERα) 2.0 × 10-11, 1 5.8 × 10-6, 4.0 × 10-6 1.3 × 10-6, 1.5 × 10-5 9.0 × 10-7, 2.2 × 10-5
SKBR3 (ERβ) 2.7 × 10-10, 1 1.8 × 10-5, 1.8 × 10-5 3.0 × 10-6, 8.9 × 10-5 8.3 × 10-8, 3.3 × 10-3
  1. Comparison of concentration for half-maximal induction (EC50) and relative estrogenic potency (REP) for E2, rhodoeosein, and emodin in human carcinoma cell-lines BG1Luc4E2 (ovarian) and SKBR3 (breast) transfected with either ERα or ERβ. Data for genistein is included for comparative purposes. REP = EC50 E2/EC50 chemical.