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Table 2 Potency comparisons of phytoestrogens

From: 2,3-cis-2R,3R-(−)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines

 

EC50(M), REP

Cell-line

E2

Rhodoeosein

Emodin

Genistein

BG1Luc4E2

1.8 × 10-11, 1

1.2 × 10-4, 3.5 × 10-7

1.3 × 10-6, 1.5 × 10-5

7.3 × 10-7, 2.5 × 10-5

SKBR3 (ERα)

2.0 × 10-11, 1

5.8 × 10-6, 4.0 × 10-6

1.3 × 10-6, 1.5 × 10-5

9.0 × 10-7, 2.2 × 10-5

SKBR3 (ERβ)

2.7 × 10-10, 1

1.8 × 10-5, 1.8 × 10-5

3.0 × 10-6, 8.9 × 10-5

8.3 × 10-8, 3.3 × 10-3

  1. Comparison of concentration for half-maximal induction (EC50) and relative estrogenic potency (REP) for E2, rhodoeosein, and emodin in human carcinoma cell-lines BG1Luc4E2 (ovarian) and SKBR3 (breast) transfected with either ERα or ERβ. Data for genistein is included for comparative purposes. REP = EC50 E2/EC50 chemical.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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