Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl 4 -induced liver injury in rodents

Table 7 Effect of aqueous extract of Terminalia paniculata on apoptotic markers in CCl ₄ -treated Chang liver cells

Groups	Phospho-p53	p53	Cleaved caspase-3	Phospho-Bad	Bad	Cleaved PARP
Normal control	0.134 ± 0.037	0.129 ± 0.020	0.126 ± 0.023	0.141 ± 0.024	0.146 ± 0.040	0.135 ± 0.042
TPW (50 μg/ml) control	0.130 ± 0.025	0.131 ± 0.028	0.123 ± 0.020	0.136 ± 0.033	0.152 ± 0.059	0.138 ± 0.066
CCl ₄ control	1.896 ± 0.081^*	2.069 ± 0.054^*	2.182 ± 0.091^*	1.758 ± 0.037^*	2.367 ± 0.072^*	2.211 ± 0.101^*
TPW (25 μg/ml) + CCl ₄	1.384 ± 0.066^*,#	1.514 ± 0.033^*,#	1.487 ± 0.040^*,#	1.324 ± 0.051^*,#	1.868 ± 0.064^*,#	1.445 ± 0.047^*,#
TPW (50 μg/ml) + CCl ₄	1.193 ± 0.050^*,#	1.148 ± 0.057^*,#	1.075 ± 0.072^*,#	1.219 ± 0.035^*,#	1.644 ± 0.049^*,#	1.117 ± 0.053^*,#

All values are expressed as mean ± SEM and experiments were carried out in triplicate. ^* p < 0.05 vs. normal control; ^# p < 0.05 vs. CCl₄ control. The levels of the apoptotic markers were expressed in terms of absorbance as per kit’s protocol.

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