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Table 7 Effect of aqueous extract of Terminalia paniculata on apoptotic markers in CCl 4 -treated Chang liver cells

From: Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl4-induced liver injury in rodents

Groups

Phospho-p53

p53

Cleaved caspase-3

Phospho-Bad

Bad

Cleaved PARP

Normal control

0.134 ± 0.037

0.129 ± 0.020

0.126 ± 0.023

0.141 ± 0.024

0.146 ± 0.040

0.135 ± 0.042

TPW (50 μg/ml) control

0.130 ± 0.025

0.131 ± 0.028

0.123 ± 0.020

0.136 ± 0.033

0.152 ± 0.059

0.138 ± 0.066

CCl 4 control

1.896 ± 0.081*

2.069 ± 0.054*

2.182 ± 0.091*

1.758 ± 0.037*

2.367 ± 0.072*

2.211 ± 0.101*

TPW (25 μg/ml) + CCl 4

1.384 ± 0.066*,#

1.514 ± 0.033*,#

1.487 ± 0.040*,#

1.324 ± 0.051*,#

1.868 ± 0.064*,#

1.445 ± 0.047*,#

TPW (50 μg/ml) + CCl 4

1.193 ± 0.050*,#

1.148 ± 0.057*,#

1.075 ± 0.072*,#

1.219 ± 0.035*,#

1.644 ± 0.049*,#

1.117 ± 0.053*,#

  1. All values are expressed as mean ± SEM and experiments were carried out in triplicate. * p < 0.05 vs. normal control; # p < 0.05 vs. CCl4 control. The levels of the apoptotic markers were expressed in terms of absorbance as per kit’s protocol.