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Table 5 Effect of the aqueous extract of Terminalia paniculata and silymarin on the hepatic enzyme activities in CCl 4 -treated rats

From: Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl4-induced liver injury in rodents

Groups AST (U/L) ALT (U/L) ALP (U/L) BilT (mg/dl)
Normal control 107.55 ± 4.65 49.05 ± 1.30 25.87 ± 3.52 0.10 ± 0.03
CCl 4 control (CCl 4 1 ml/kg, i.p.) 589.04 ± 10.12# 298.21 ± 10.55# 175.51 ± 6.84# 1.05 ± 0.12#
Silymarin (100 mg/kg, p.o.) 243.02 ± 8.80* 107.72 ± 8.24* 48.63 ± 15.30* 0.23 ± 0.11*
TPW
(400 mg/kg, p.o.)
272.33 ± 26.8* 131.27 ± 5.31* 65.66 ± 5.24* 0.30 ± 0.10*
  1. TPW aqueous extract of Terminalia paniculata, AST asparate transferase; ALT alanine transferase, ALP alkaline phosphatase, BilT – total bilirubin.
  2. Data represented as mean ± S.E.M (n = 6), analysed by one-way ANOVA followed by Dunnett’s post hoc test. # p < 0.05 as compared to normal control, *p < 0.05 as compared to CCl4 group.
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