Parameter unit sex
|
Hematological values
|
---|
0 mg/kg
|
1000 mg/kg
|
2500 mg/kg
|
5000 mg/kg
|
---|
13 wk
|
26 wk
|
Recovery
|
13 wk
|
26 wk
|
Recovery
|
13 wk
|
26 wk
|
Recovery
|
13wk
|
26 wk
|
Recovery
|
---|
RBC
|
1012/L
|
Male
|
9.18 ± 0.31
|
8.86 ± 0.47
|
8.65 ± 0.32
|
9.04 ± 0.33
|
8.72 ± 0.40
|
8.83 ± 0.45
|
9.27 ± 0.29
|
8.21 ± 0.71
|
8.48 ± 0.35
|
8.99 ± 0.80
|
8.94 ± 0.50
|
9.07 ± 0.71
|
Female
|
8.11 ± 0.28
|
7.90 ± 0.49
|
7.59 ± 0.55
|
8.30 ± 0.28
|
7.85 ± 0.69
|
8.01 ± 0.72
|
8.37 ± 0.79
|
7.84 ± 0.49
|
7.65 ± 0.41
|
8.58 ± 0.66
|
6.96 ± 1.47
|
7.90 ± 0.55
|
HGB
|
g/L
|
Male
|
174 ± 6
|
168 ± 6
|
170 ± 7
|
164 ± 7
|
166 ± 3
|
166 ± 3
|
171 ± 5
|
157 ± 11**
|
163 ± 5
|
168 ± 6
|
162 ± 6*
|
174 ± 8
|
Female
|
158 ± 2
|
162 ± 7
|
159 ± 10
|
163 ± 4
|
156 ± 12
|
167 ± 11
|
166 ± 10
|
155 ± 8
|
160 ± 10
|
166 ± 12
|
137 ± 29*
|
162 ± 4
|
HCT
|
%
|
Male
|
45.3 ± 1.3
|
43.7 ± 1.8
|
44.1 ± 1.8
|
43.9 ± 1.2
|
44.1 ± 1.1
|
43.3 ± 0.9
|
44.9 ± 1.3
|
42.2 ± 3.2
|
43.0 ± 1.4
|
44.4 ± 2.5
|
45.0 ± 2.4
|
46.5 ± 2.4
|
Female
|
40.8 ± 1.2
|
42.2 ± 2.3
|
40.7 ± 2.8
|
41.9 ± 1.2
|
41.6 ± 2.9
|
44.3 ± 3.1
|
42.2 ± 3.3
|
41.7 ± 2.4
|
41.0 ± 3.0
|
42.7 ± 2.6
|
37.8 ± 7.8
|
41.0 ± 1.7
|
MCV
|
fL
|
Male
|
49.3 ± 0.7
|
49.3 ± 1.2
|
51.0 ± 1.9
|
48.6 ± 1.7
|
50.6 ± 1.5
|
49.1 ± 1.6
|
48.4 ± 0.8
|
51.5 ± 1.8
|
50.7 ± 2.1
|
49.6 ± 3.3
|
50.3 ± 1.7
|
51.4 ± 1.5
|
Female
|
50.3 ± 1.4
|
53.5 ± 1.3
|
53.7 ± 2.4
|
50.5 ± 1.7
|
53.0 ± 1.7
|
55.4 ± 1.5
|
50.4 ± 0.9
|
53.2 ± 1.7
|
53.6 ± 1.3
|
49.8 ± 1.1
|
54.4 ± 1.6
|
52.0 ± 1.7
|
MCH
|
pg
|
Male
|
19.0 ± 0.2
|
19.0 ± 0.6
|
19.7 ± 0.8
|
18.1 ± 0.5
|
19.1 ± 0.7
|
18.8 ± 0.9
|
18.4 ± 0.3
|
19.1 ± 0.9
|
19.3 ± 0.7
|
18.8 ± 1.4
|
18.1 ± 0.7*
|
19.2 ± 0.7
|
Female
|
19.5 ± 0.7
|
20.6 ± 0.5
|
21.0 ± 0.8
|
19.7 ± 0.6
|
19.9 ± 0.7**
|
20.9 ± 0.8
|
19.9 ± 0.9
|
19.8 ± 0.6*
|
20.9 ± 0.5
|
19.4 ± 1.0
|
19.7 ± 0.9**
|
20.6 ± 0.9
|
MCHC
|
g/L
|
Male
|
385 ± 6
|
385 ± 7
|
386 ± 9
|
373 ± 9
|
376 ± 7*
|
383 ± 6
|
381 ± 4
|
371 ± 13*
|
380 ± 5
|
378 ± 10
|
361 ± 8*
|
374 ± 4*
|
Female
|
387 ± 8
|
385 ± 6
|
391 ± 8
|
389 ± 3
|
376 ± 7*
|
378 ± 8
|
395 ± 12
|
373 ± 6*
|
389 ± 8
|
389 ± 17
|
362 ± 16*
|
395 ± 7
|
RDW
|
%
|
Male
|
13.6 ± 0.5
|
13.3 ± 0.5
|
13.5 ± 0.4
|
13.7 ± 0.2
|
13.3 ± 0.3
|
13.4 ± 0.3
|
13.5 ± 0.3
|
13.3 ± 0.5
|
13.4 ± 0.5
|
13.7 ± 0.3
|
13.4 ± 0.4
|
13.4 ± 0.7
|
Female
|
13.1 ± 0.3
|
12.8 ± 0.3
|
12.6 ± 0.3
|
13.0 ± 0.3
|
12.7 ± 0.3
|
12.5 ± 0.2
|
12.9 ± 0.3
|
12.6 ± 0.3
|
12.9 ± 0.2
|
12.8 ± 0.3
|
13.0 ± 0.4
|
12.6 ± 0.5
|
PLT
|
109/L
|
Male
|
823 ± 87
|
906 ± 48
|
881 ± 107
|
797 ± 106
|
831 ± 71
|
906 ± 76
|
816 ± 39
|
819 ± 74
|
872 ± 42
|
795 ± 30
|
854 ± 69
|
940 ± 99
|
Female
|
763 ± 55
|
756 ± 98
|
828 ± 60
|
859 ± 122
|
816 ± 62
|
936 ± 72
|
810 ± 45
|
792 ± 94
|
839 ± 91
|
848 ± 86
|
696 ± 271
|
865 ± 76
|
MPV
|
fL
|
Male
|
3.3 ± 0.4
|
3.7 ± 0.5
|
4.2 ± 0.7
|
3.3 ± 0.4
|
3.7 ± 0.4
|
4.2 ± 0.4
|
3.4 ± 0.4
|
3.9 ± 0.5
|
4.2 ± 0.4
|
3.5 ± 0.4
|
4.7 ± 0.5**
|
4.5 ± 0.6
|
Female
|
3.4 ± 0.4
|
3.7 ± 0.5
|
4.1 ± 0.9
|
3.4 ± 0.4
|
4.0 ± 0.5
|
4.5 ± 0.2
|
3.5 ± 0.2
|
4.0 ± 0.6
|
4.4 ± 0.5
|
3.5 ± 0.4
|
4.6 ± 1.6
|
4.0 ± 0.2
|
PDW
|
%
|
Male
|
14.8 ± 0.5
|
14.4 ± 0.3
|
14.3 ± 0.6
|
15.3 ± 0.4
|
14.3 ± 0.6
|
13.9 ± 0.2
|
14.9 ± 0.5
|
14.3 ± 0.4
|
14.4 ± 0.5
|
15.2 ± 1.0
|
14.3 ± 0.4
|
14.6 ± 0.6
|
| |
Female
|
15.0 ± 0.5
|
14.7 ± 0.3
|
14.4 ± 0.6
|
14.9 ± 0.4
|
14.7 ± 0.4
|
15.1 ± 0.8
|
15.3 ± 0.8
|
14.6 ± 0.6
|
14.5 ± 0.7
|
15.3 ± 0.6
|
15.2 ± 1.9
|
14.1 ± 0.2
|
PT
|
s
|
Male
|
14.4 ± 1.8
|
19.0 ± 5.8
|
15.1 ± 0.9
|
18.1 ± 3.9
|
17.1 ± 4.4
|
15.1 ± 0.4
|
13.5 ± 0.4
|
15.2 ± 3.2
|
14.7 ± 0.4
|
15.2 ± 2.6
|
15.7 ± 3.4
|
14.5 ± 0.6
|
Female
|
12.7 ± 0.6
|
13.4 ± 0.6
|
14.5 ± 0.5
|
12.4 ± 0.5
|
13.3 ± 0.5
|
14.4 ± 0.6
|
12.5 ± 0.3
|
13.7 ± 0.7
|
13.9 ± 0.5
|
12.5 ± 0.8
|
13.2 ± 1.0
|
14.1 ± 1.2
|
WBC
|
109/L
|
Male
|
6.4 ± 0.4
|
4.6 ± 1.1
|
4.7 ± 1.6
|
8.5 ± 3.4
|
6.6 ± 1.2**
|
5.2 ± 2.1
|
10.5 ± 2.7**
|
6.1 ± 2.3
|
5.2 ± 0.9
|
11.9 ± 2.2*
|
6.5 ± 2.2*
|
5.5 ± 1.2
|
Female
|
4.3 ± 1.2
|
3.1 ± 0.9
|
2.3 ± 0.6
|
6.0 ± 1.4
|
2.8 ± 0.8
|
2.4 ± 0.5
|
6.6 ± 2.5
|
3.1 ± 0.8
|
2.3 ± 0.6
|
6.9 ± 1.3
|
2.7 ± 1.2
|
2.7 ± 0.6
|
LYM
|
109/L
|
Male
|
5.0 ± 0.4
|
3.9 ± 0.9
|
4.1 ± 1.3
|
6.7 ± 3.1
|
5.3 ± 0.9**
|
4.4 ± 1.8
|
7.6 ± 1.8*
|
4.8 ± 1.8
|
4.3 ± 0.6
|
9.3 ± 2.1**
|
4.9 ± 1.6
|
4.4 ± 0.9
|
Female
|
3.5 ± 1.1
|
2.5 ± 0.7
|
1.9 ± 0.5
|
4.8 ± 0.8
|
2.2 ± 0.6
|
2.0 ± 0.4
|
5.3 ± 2.0
|
2.5 ± 0.6
|
1.9 ± 0.5
|
5.8 ± 1.4*
|
2.2 ± 1.0
|
2.2 ± 0.4
|
MON
|
109/L
|
Male
|
0.1 ± 0.0
|
0.0 ± 0.1
|
0.0 ± 0.0
|
0.2 ± 0.1
|
0.1 ± 0.0
|
0.0 ± 0.0
|
0.2 ± 0.2
|
0.1 ± 0.1
|
0.0 ± 0.0
|
0.3 ± 0.1
|
0.1 ± 0.1
|
0.1 ± 0.0
|
Female
|
0.1 ± 0.1
|
0.1 ± 0.2
|
0.0 ± 0.0
|
0.1 ± 0.1
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.2 ± 0.1
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.2 ± 0.1
|
0.0 ± 0.0
|
0.0 ± 0.0
|
NE
|
109/L
|
Male
|
1.2 ± 0.3
|
0.6 ± 0.2
|
0.6 ± 0.3
|
1.6 ± 0.5
|
1.2 ± 0.3**
|
0.8 ± 0.3
|
2.6 ± 0.8**
|
1.2 ± 0.5**
|
0.9 ± 0.2
|
2.2 ± 0.4**
|
1.5 ± 0.7**
|
1.1 ± 0.3
|
Female
|
0.7 ± 0.3
|
0.5 ± 0.2
|
0.3 ± 0.1
|
1.0 ± 0.7
|
0.6 ± 0.2
|
0.4 ± 0.1
|
1.1 ± 0.7
|
0.6 ± 0.1
|
0.4 ± 0.1
|
0.9 ± 0.3
|
0.5 ± 0.2
|
0.5 ± 0.1
|
EOS
|
109/L
|
Male
|
0.0 ± 0.1
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.1 ± 0.1
|
0.0 ± 0.0
|
0.0 ± 0.0
|
Female
|
0.0 ± 0.1
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.1 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.1
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.1
|
0.0 ± 0.0
|
0.0 ± 0.0
|
BAS
|
109/L
|
Male
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
Female
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
0.0 ± 0.0
|
LYM
|
%
|
Male
|
77.7 ± 4.5
|
84.9 ± 0.9
|
86.7 ± 1.0
|
77.5 ± 5.2
|
80.7 ± 2.7**
|
83.4 ± 0.6**
|
72.8 ± 4.0
|
77.3 ± 2.4*
|
80.8 ± 1.8**
|
78.0 ± 4.7
|
75.9 ± 3.6**
|
79.0 ± 3.1**
|
Female
|
80.2 ± 6.1
|
80.0 ± 2.1
|
85.7 ± 0.7
|
80.3 ± 7.7
|
77.5 ± 3.7
|
83.9 ± 1.4*
|
79.8 ± 7.8
|
77.2 ± 2.3*
|
81.7 ± 2.6*
|
81.7 ± 6.2
|
78.9 ± 4.9
|
80.0 ± 2.0**
|
MON
|
%
|
Male
|
1.8 ± 0.3
|
1.1 ± 0.5
|
0.4 ± 0.1
|
1.9 ± 1.1
|
1.1 ± 0.4
|
0.5 ± 0.3
|
2.3 ± 0.7
|
1.4 ± 0.7
|
0.5 ± 0.2
|
2.7 ± 0.6
|
1.3 ± 0.5
|
1.1 ± 0.4
|
Female
|
1.5 ± 0.5
|
2.4 ± 4.3
|
0.3 ± 0.2
|
2.6 ± 0.5
|
0.9 ± 0.4
|
0.3 ± 0.3
|
2.7 ± 1.1
|
1.2 ± 0.6
|
0.6 ± 0.4
|
3.0 ± 0.6
|
0.9 ± 0.6
|
0.5 ± 0.3
|
NE
|
%
|
Male
|
19.5 ± 4.8
|
13.4 ± 0.7
|
12.3 ± 1.1
|
20.0 ± 4.8
|
17.6 ± 3.0**
|
15.8 ± 0.6
|
24.5 ± 4.0
|
20.6 ± 2.6*
|
18.1 ± 1.7
|
18.7 ± 4.3
|
22.0 ± 3.6**
|
19.3 ± 3.4
|
Female
|
16.8 ± 6.3
|
16.9 ± 4.4
|
13.8 ± 0.7
|
15.5 ± 7.9
|
20.7 ± 3.5
|
15.2 ± 1.5
|
16.6 ± 8.7
|
20.6 ± 2.7*
|
16.7 ± 2.6
|
14.2 ± 6.0
|
19.3 ± 4.1
|
18.7 ± 1.8
|
EOS
|
%
|
Male
|
0.7 ± 0.3
|
0.4 ± 0.3
|
0.4 ± 0.4 0
|
0.4 ± 0.3
|
0.3 ± 0.2
|
0.2 ± 0.1
|
0.3 ± 0.2
|
0.4 ± 0.3
|
0.4 ± 0.3
|
0.5 ± 0.2
|
0.5 ± 0.4
|
0.4 ± 0.2
|
Female
|
1.2 ± 0.2
|
0.5 ± 0.2
|
0.1 ± 0.1
|
1.0 ± 0.3
|
0.5 ± 0.2
|
0.5 ± 0.1
|
0.7 ± 0.5
|
0.7 ± 0.5
|
0.8 ± 0.6
|
0.8 ± 0.4
|
0.8 ± 0.5
|
0.5 ± 0.4
|
BAS
|
%
|
Male
|
0.3 ± 0.1
|
0.3 ± 0.2
|
0.2 ± 0.1
|
0.2 ± 0.2
|
0.3 ± 0.2
|
0.2 ± 0.1
|
0.1 ± 0.1
|
0.3 ± 0.2
|
0.1 ± 0.1
|
0.1 ± 0.1
|
0.3 ± 0.1
|
0.2 ± 0.0
|
Female
|
0.2 ± 0.2
|
0.3 ± 0.3
|
0.1 ± 0.1
|
0.5 ± 0.2
|
0.4 ± 0.3
|
0.1 ± 0.1
|
0.2 ± 0.3
|
0.2 ± 0.2
|
0.2 ± 0.3
|
0.3 ± 0.1
|
0.1 ± 0.2
|
0.2 ± 0.3
|
RET
|
‰
|
Male
|
11 ± 4
|
21 ± 5
|
10 ± 3
|
14 ± 6
|
18 ± 3
|
12 ± 2
|
16 ± 3*
|
18 ± 7
|
11 ± 4
|
14 ± 4
|
21 ± 5
|
11 ± 4
|
| |
Female
|
18 ± 4
|
21 ± 4
|
10 ± 3
|
19 ± 5
|
22 ± 4
|
17 ± 2
|
18 ± 4
|
18 ± 6
|
11 ± 3
|
14 ± 4
|
28 ± 7
|
10 ± 4
|
- Note: Red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular HGB (MCH), mean corpuscular HGB concentration (MCHC), red cell distribution width (RDW), platelets (PLT), mean platelet volume (MPV), platelet distribution width (PDW), white blood cell (WBC) counts, reticulocytes (RET), neutrophils (NE), lymphocytes (LYM), monocytes (MON), eosinophils (EOS), and basophils (BAS) prothrombin time (PT). Values are mean ± S.D. (n = 5 (4 weeks), 10 (26 weeks) or recovery (30 weeks)/sex/dose). * P < 0.05 & ** P < 0.01 compared with normal group.