Parameter unit sex | Hematological values | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0 mg/kg | 1000 mg/kg | 2500 mg/kg | 5000 mg/kg | |||||||||||
13 wk | 26 wk | Recovery | 13 wk | 26 wk | Recovery | 13 wk | 26 wk | Recovery | 13wk | 26 wk | Recovery | |||
RBC | 1012/L | Male | 9.18 ± 0.31 | 8.86 ± 0.47 | 8.65 ± 0.32 | 9.04 ± 0.33 | 8.72 ± 0.40 | 8.83 ± 0.45 | 9.27 ± 0.29 | 8.21 ± 0.71 | 8.48 ± 0.35 | 8.99 ± 0.80 | 8.94 ± 0.50 | 9.07 ± 0.71 |
Female | 8.11 ± 0.28 | 7.90 ± 0.49 | 7.59 ± 0.55 | 8.30 ± 0.28 | 7.85 ± 0.69 | 8.01 ± 0.72 | 8.37 ± 0.79 | 7.84 ± 0.49 | 7.65 ± 0.41 | 8.58 ± 0.66 | 6.96 ± 1.47 | 7.90 ± 0.55 | ||
HGB | g/L | Male | 174 ± 6 | 168 ± 6 | 170 ± 7 | 164 ± 7 | 166 ± 3 | 166 ± 3 | 171 ± 5 | 157 ± 11** | 163 ± 5 | 168 ± 6 | 162 ± 6* | 174 ± 8 |
Female | 158 ± 2 | 162 ± 7 | 159 ± 10 | 163 ± 4 | 156 ± 12 | 167 ± 11 | 166 ± 10 | 155 ± 8 | 160 ± 10 | 166 ± 12 | 137 ± 29* | 162 ± 4 | ||
HCT | % | Male | 45.3 ± 1.3 | 43.7 ± 1.8 | 44.1 ± 1.8 | 43.9 ± 1.2 | 44.1 ± 1.1 | 43.3 ± 0.9 | 44.9 ± 1.3 | 42.2 ± 3.2 | 43.0 ± 1.4 | 44.4 ± 2.5 | 45.0 ± 2.4 | 46.5 ± 2.4 |
Female | 40.8 ± 1.2 | 42.2 ± 2.3 | 40.7 ± 2.8 | 41.9 ± 1.2 | 41.6 ± 2.9 | 44.3 ± 3.1 | 42.2 ± 3.3 | 41.7 ± 2.4 | 41.0 ± 3.0 | 42.7 ± 2.6 | 37.8 ± 7.8 | 41.0 ± 1.7 | ||
MCV | fL | Male | 49.3 ± 0.7 | 49.3 ± 1.2 | 51.0 ± 1.9 | 48.6 ± 1.7 | 50.6 ± 1.5 | 49.1 ± 1.6 | 48.4 ± 0.8 | 51.5 ± 1.8 | 50.7 ± 2.1 | 49.6 ± 3.3 | 50.3 ± 1.7 | 51.4 ± 1.5 |
Female | 50.3 ± 1.4 | 53.5 ± 1.3 | 53.7 ± 2.4 | 50.5 ± 1.7 | 53.0 ± 1.7 | 55.4 ± 1.5 | 50.4 ± 0.9 | 53.2 ± 1.7 | 53.6 ± 1.3 | 49.8 ± 1.1 | 54.4 ± 1.6 | 52.0 ± 1.7 | ||
MCH | pg | Male | 19.0 ± 0.2 | 19.0 ± 0.6 | 19.7 ± 0.8 | 18.1 ± 0.5 | 19.1 ± 0.7 | 18.8 ± 0.9 | 18.4 ± 0.3 | 19.1 ± 0.9 | 19.3 ± 0.7 | 18.8 ± 1.4 | 18.1 ± 0.7* | 19.2 ± 0.7 |
Female | 19.5 ± 0.7 | 20.6 ± 0.5 | 21.0 ± 0.8 | 19.7 ± 0.6 | 19.9 ± 0.7** | 20.9 ± 0.8 | 19.9 ± 0.9 | 19.8 ± 0.6* | 20.9 ± 0.5 | 19.4 ± 1.0 | 19.7 ± 0.9** | 20.6 ± 0.9 | ||
MCHC | g/L | Male | 385 ± 6 | 385 ± 7 | 386 ± 9 | 373 ± 9 | 376 ± 7* | 383 ± 6 | 381 ± 4 | 371 ± 13* | 380 ± 5 | 378 ± 10 | 361 ± 8* | 374 ± 4* |
Female | 387 ± 8 | 385 ± 6 | 391 ± 8 | 389 ± 3 | 376 ± 7* | 378 ± 8 | 395 ± 12 | 373 ± 6* | 389 ± 8 | 389 ± 17 | 362 ± 16* | 395 ± 7 | ||
RDW | % | Male | 13.6 ± 0.5 | 13.3 ± 0.5 | 13.5 ± 0.4 | 13.7 ± 0.2 | 13.3 ± 0.3 | 13.4 ± 0.3 | 13.5 ± 0.3 | 13.3 ± 0.5 | 13.4 ± 0.5 | 13.7 ± 0.3 | 13.4 ± 0.4 | 13.4 ± 0.7 |
Female | 13.1 ± 0.3 | 12.8 ± 0.3 | 12.6 ± 0.3 | 13.0 ± 0.3 | 12.7 ± 0.3 | 12.5 ± 0.2 | 12.9 ± 0.3 | 12.6 ± 0.3 | 12.9 ± 0.2 | 12.8 ± 0.3 | 13.0 ± 0.4 | 12.6 ± 0.5 | ||
PLT | 109/L | Male | 823 ± 87 | 906 ± 48 | 881 ± 107 | 797 ± 106 | 831 ± 71 | 906 ± 76 | 816 ± 39 | 819 ± 74 | 872 ± 42 | 795 ± 30 | 854 ± 69 | 940 ± 99 |
Female | 763 ± 55 | 756 ± 98 | 828 ± 60 | 859 ± 122 | 816 ± 62 | 936 ± 72 | 810 ± 45 | 792 ± 94 | 839 ± 91 | 848 ± 86 | 696 ± 271 | 865 ± 76 | ||
MPV | fL | Male | 3.3 ± 0.4 | 3.7 ± 0.5 | 4.2 ± 0.7 | 3.3 ± 0.4 | 3.7 ± 0.4 | 4.2 ± 0.4 | 3.4 ± 0.4 | 3.9 ± 0.5 | 4.2 ± 0.4 | 3.5 ± 0.4 | 4.7 ± 0.5** | 4.5 ± 0.6 |
Female | 3.4 ± 0.4 | 3.7 ± 0.5 | 4.1 ± 0.9 | 3.4 ± 0.4 | 4.0 ± 0.5 | 4.5 ± 0.2 | 3.5 ± 0.2 | 4.0 ± 0.6 | 4.4 ± 0.5 | 3.5 ± 0.4 | 4.6 ± 1.6 | 4.0 ± 0.2 | ||
PDW | % | Male | 14.8 ± 0.5 | 14.4 ± 0.3 | 14.3 ± 0.6 | 15.3 ± 0.4 | 14.3 ± 0.6 | 13.9 ± 0.2 | 14.9 ± 0.5 | 14.3 ± 0.4 | 14.4 ± 0.5 | 15.2 ± 1.0 | 14.3 ± 0.4 | 14.6 ± 0.6 |
 |  | Female | 15.0 ± 0.5 | 14.7 ± 0.3 | 14.4 ± 0.6 | 14.9 ± 0.4 | 14.7 ± 0.4 | 15.1 ± 0.8 | 15.3 ± 0.8 | 14.6 ± 0.6 | 14.5 ± 0.7 | 15.3 ± 0.6 | 15.2 ± 1.9 | 14.1 ± 0.2 |
PT | s | Male | 14.4 ± 1.8 | 19.0 ± 5.8 | 15.1 ± 0.9 | 18.1 ± 3.9 | 17.1 ± 4.4 | 15.1 ± 0.4 | 13.5 ± 0.4 | 15.2 ± 3.2 | 14.7 ± 0.4 | 15.2 ± 2.6 | 15.7 ± 3.4 | 14.5 ± 0.6 |
Female | 12.7 ± 0.6 | 13.4 ± 0.6 | 14.5 ± 0.5 | 12.4 ± 0.5 | 13.3 ± 0.5 | 14.4 ± 0.6 | 12.5 ± 0.3 | 13.7 ± 0.7 | 13.9 ± 0.5 | 12.5 ± 0.8 | 13.2 ± 1.0 | 14.1 ± 1.2 | ||
WBC | 109/L | Male | 6.4 ± 0.4 | 4.6 ± 1.1 | 4.7 ± 1.6 | 8.5 ± 3.4 | 6.6 ± 1.2** | 5.2 ± 2.1 | 10.5 ± 2.7** | 6.1 ± 2.3 | 5.2 ± 0.9 | 11.9 ± 2.2* | 6.5 ± 2.2* | 5.5 ± 1.2 |
Female | 4.3 ± 1.2 | 3.1 ± 0.9 | 2.3 ± 0.6 | 6.0 ± 1.4 | 2.8 ± 0.8 | 2.4 ± 0.5 | 6.6 ± 2.5 | 3.1 ± 0.8 | 2.3 ± 0.6 | 6.9 ± 1.3 | 2.7 ± 1.2 | 2.7 ± 0.6 | ||
LYM | 109/L | Male | 5.0 ± 0.4 | 3.9 ± 0.9 | 4.1 ± 1.3 | 6.7 ± 3.1 | 5.3 ± 0.9** | 4.4 ± 1.8 | 7.6 ± 1.8* | 4.8 ± 1.8 | 4.3 ± 0.6 | 9.3 ± 2.1** | 4.9 ± 1.6 | 4.4 ± 0.9 |
Female | 3.5 ± 1.1 | 2.5 ± 0.7 | 1.9 ± 0.5 | 4.8 ± 0.8 | 2.2 ± 0.6 | 2.0 ± 0.4 | 5.3 ± 2.0 | 2.5 ± 0.6 | 1.9 ± 0.5 | 5.8 ± 1.4* | 2.2 ± 1.0 | 2.2 ± 0.4 | ||
MON | 109/L | Male | 0.1 ± 0.0 | 0.0 ± 0.1 | 0.0 ± 0.0 | 0.2 ± 0.1 | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.2 ± 0.2 | 0.1 ± 0.1 | 0.0 ± 0.0 | 0.3 ± 0.1 | 0.1 ± 0.1 | 0.1 ± 0.0 |
Female | 0.1 ± 0.1 | 0.1 ± 0.2 | 0.0 ± 0.0 | 0.1 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.2 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.2 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 | ||
NE | 109/L | Male | 1.2 ± 0.3 | 0.6 ± 0.2 | 0.6 ± 0.3 | 1.6 ± 0.5 | 1.2 ± 0.3** | 0.8 ± 0.3 | 2.6 ± 0.8** | 1.2 ± 0.5** | 0.9 ± 0.2 | 2.2 ± 0.4** | 1.5 ± 0.7** | 1.1 ± 0.3 |
Female | 0.7 ± 0.3 | 0.5 ± 0.2 | 0.3 ± 0.1 | 1.0 ± 0.7 | 0.6 ± 0.2 | 0.4 ± 0.1 | 1.1 ± 0.7 | 0.6 ± 0.1 | 0.4 ± 0.1 | 0.9 ± 0.3 | 0.5 ± 0.2 | 0.5 ± 0.1 | ||
EOS | 109/L | Male | 0.0 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.1 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Female | 0.0 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 | ||
BAS | 109/L | Male | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Female | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | ||
LYM | % | Male | 77.7 ± 4.5 | 84.9 ± 0.9 | 86.7 ± 1.0 | 77.5 ± 5.2 | 80.7 ± 2.7** | 83.4 ± 0.6** | 72.8 ± 4.0 | 77.3 ± 2.4* | 80.8 ± 1.8** | 78.0 ± 4.7 | 75.9 ± 3.6** | 79.0 ± 3.1** |
Female | 80.2 ± 6.1 | 80.0 ± 2.1 | 85.7 ± 0.7 | 80.3 ± 7.7 | 77.5 ± 3.7 | 83.9 ± 1.4* | 79.8 ± 7.8 | 77.2 ± 2.3* | 81.7 ± 2.6* | 81.7 ± 6.2 | 78.9 ± 4.9 | 80.0 ± 2.0** | ||
MON | % | Male | 1.8 ± 0.3 | 1.1 ± 0.5 | 0.4 ± 0.1 | 1.9 ± 1.1 | 1.1 ± 0.4 | 0.5 ± 0.3 | 2.3 ± 0.7 | 1.4 ± 0.7 | 0.5 ± 0.2 | 2.7 ± 0.6 | 1.3 ± 0.5 | 1.1 ± 0.4 |
Female | 1.5 ± 0.5 | 2.4 ± 4.3 | 0.3 ± 0.2 | 2.6 ± 0.5 | 0.9 ± 0.4 | 0.3 ± 0.3 | 2.7 ± 1.1 | 1.2 ± 0.6 | 0.6 ± 0.4 | 3.0 ± 0.6 | 0.9 ± 0.6 | 0.5 ± 0.3 | ||
NE | % | Male | 19.5 ± 4.8 | 13.4 ± 0.7 | 12.3 ± 1.1 | 20.0 ± 4.8 | 17.6 ± 3.0** | 15.8 ± 0.6 | 24.5 ± 4.0 | 20.6 ± 2.6* | 18.1 ± 1.7 | 18.7 ± 4.3 | 22.0 ± 3.6** | 19.3 ± 3.4 |
Female | 16.8 ± 6.3 | 16.9 ± 4.4 | 13.8 ± 0.7 | 15.5 ± 7.9 | 20.7 ± 3.5 | 15.2 ± 1.5 | 16.6 ± 8.7 | 20.6 ± 2.7* | 16.7 ± 2.6 | 14.2 ± 6.0 | 19.3 ± 4.1 | 18.7 ± 1.8 | ||
EOS | % | Male | 0.7 ± 0.3 | 0.4 ± 0.3 | 0.4 ± 0.4 0 | 0.4 ± 0.3 | 0.3 ± 0.2 | 0.2 ± 0.1 | 0.3 ± 0.2 | 0.4 ± 0.3 | 0.4 ± 0.3 | 0.5 ± 0.2 | 0.5 ± 0.4 | 0.4 ± 0.2 |
Female | 1.2 ± 0.2 | 0.5 ± 0.2 | 0.1 ± 0.1 | 1.0 ± 0.3 | 0.5 ± 0.2 | 0.5 ± 0.1 | 0.7 ± 0.5 | 0.7 ± 0.5 | 0.8 ± 0.6 | 0.8 ± 0.4 | 0.8 ± 0.5 | 0.5 ± 0.4 | ||
BAS | % | Male | 0.3 ± 0.1 | 0.3 ± 0.2 | 0.2 ± 0.1 | 0.2 ± 0.2 | 0.3 ± 0.2 | 0.2 ± 0.1 | 0.1 ± 0.1 | 0.3 ± 0.2 | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.3 ± 0.1 | 0.2 ± 0.0 |
Female | 0.2 ± 0.2 | 0.3 ± 0.3 | 0.1 ± 0.1 | 0.5 ± 0.2 | 0.4 ± 0.3 | 0.1 ± 0.1 | 0.2 ± 0.3 | 0.2 ± 0.2 | 0.2 ± 0.3 | 0.3 ± 0.1 | 0.1 ± 0.2 | 0.2 ± 0.3 | ||
RET | ‰ | Male | 11 ± 4 | 21 ± 5 | 10 ± 3 | 14 ± 6 | 18 ± 3 | 12 ± 2 | 16 ± 3* | 18 ± 7 | 11 ± 4 | 14 ± 4 | 21 ± 5 | 11 ± 4 |
 |  | Female | 18 ± 4 | 21 ± 4 | 10 ± 3 | 19 ± 5 | 22 ± 4 | 17 ± 2 | 18 ± 4 | 18 ± 6 | 11 ± 3 | 14 ± 4 | 28 ± 7 | 10 ± 4 |