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Table 2 Absolute & relative organ weights in rats orally treated with HZJW

From: Gastroprotective and anti-Helicobacter pylori potential of herbal formula HZJW: safety and efficacy assessment

Parameter

Sex

Dose (mg/kg)

0 mg/kg

1000 mg/kg

2500 mg/kg

5000 mg/kg

13 wk

26 wk

Recovery

13 wk

26 wk

Recovery

13 wk

26 wk

Recovery

13wk

26 wk

Recovery

Body weight

Male

486.2 ± 16.4

604.4 ± 70.0

641.3 ± 95.7

516.3 ± 101.3

634.6 ± 60.1

670.7 ± 65.7

482.3 ± 44.4

628.1 ± 67.7

660.4 ± 39.7

481.8 ± 39.5

637.8 ± 82.5

691.7 ± 63.8

Female

291.3 ± 16.8

331.8 ± 27.2

338.9 ± 35.6

280.9 ± 17.0

333.4 ± 32.2

329.7 ± 34.7

266.0 ± 9.3

308.3 ± 25.7

318.4 ± 15.2

269.0 ± 36.4

322.2 ± 31.9

336.6 ± 29.5

Brain

Male

2.096 ± 0.064

2.240 ± 0.124

2.163 ± 0.103

2.214 ± 0.115

2.221 ± 0.095

2.191 ± 0.090

2.080 ± 0.117

2.281 ± 0.079

2.224 ± 0.092

2.092 ± 0.183

2.238 ± 0.089

2.261 ± 0.049

Female

1.996 ± 0.066

2.021 ± 0.064

2.088 ± 0.096

1.947 ± 0.040

2.011 ± 0.064

2.028 ± 0.043

2.006 ± 0.046

2.008 ± 0.105

2.003 ± 0.063

1.985 ± 0.029

2.040 ± 0.060

2.029 ± 0.039

% to body weight

Male

0.431 ± .016

0.376 ± 0.054

0.344 ± 0.055

0.439 ± 0.067

0.352 ± 0.033

0.329 ± 0.034

0.434 ± 0.039

0.366 ± 0.036

0.338 ± 0.027

0.436 ± 0.043

0.356 ± 0.046

0.329 ± 0.030

Female

0.687 ± 0.041

0.612 ± 0.041

0.621 ± 0.066

0.695 ± 0.045

0.608 ± 0.060

0.620 ± 0.065

0.754 ± 0.023*

0.655 ± 0.057

0.630 ± 0.019

0.747 ± 0.082

0.638 ± 0.065

0.606 ± 0.051

Thymus

Male

0.297 ± 0.097

0.270 ± 0.069

0.262 ± 0.063

0.351 ± 0.170

0.219 ± 0.106

0.250 ± 0.092

0.313 ± 0.043

0.223 ± 0.084

0.200 ± 0.038

0.270 ± 0.048

0.262 ± 0.056

0.224 ± 0.059

Female

0.367 ± 0.057

0.245 ± 0.073

0.187 ± 0.057

0.325 ± 0.041

0.232 ± 0.038

0.225 ± 0.045

0.283 ± 0.053

0.226 ± 0.061

0.214 ± 0.071

0.304 ± 0.091

0.231 ± 0.063

0.218 ± 0.023

% to body weight

Male

0.061 ± 0.018

0.044 ± 0.009

0.041 ± 0.008

0.065 ± 0.019

0.034 ± 0.013*

0.037 ± 0.013

0.065 ± 0.011

0.035 ± 0.012

0.030 ± 0.005*

0.056 ± 0.008

0.041 ± 0.008

0.032 ± 0.006

Female

0.126 ± 0.017

0.074 ± 0.023

0.055 ± 0.014

0.116 ± 0.015

0.070 ± 0.010

0.069 ± 0.015

0.106 ± 0.018

0.073 ± 0.017

0.067 ± 0.021

0.112 ± 0.026

0.071 ± 0.014

0.065 ± 0.009

Heart

Male

1.381 ± 0.111

1.625 ± 0.204

1.653 ± 0.259

1.494 ± 0.193

1.710 ± 0.229

1.613 ± 0.225

1.408 ± 0.156

1.702 ± 0.169

1.749 ± 0.138

1.467 ± 0.093

1.699 ± 0.182

1.912 ± 0.182

Female

0.832 ± 0.042

1.100 ± 0.101

1.046 ± 0.138

0.917 ± 0.094

1.089 ± 0.109

1.013 ± 0.091

0.905 ± 0.066

1.024 ± 0.091

0.986 ± 0.069

0.969 ± 0.102

1.098 ± 0.136

1.014 ± 0.068

% to body weight

Male

0.284 ± 0.014

0.270 ± 0.029

0.258 ± 0.004

0.294 ± 0.037

0.271 ± 0.039

0.240 ± 0.015*

0.292 ± 0.021

0.272 ± 0.021

0.265 ± 0.020

0.306 ± 0.028

0.268 ± 0.016

0.277 ± 0.016

Female

0.286 ± 0.012

0.333 ± 0.034

0.308 ± 0.010

0.326 ± 0.023*

0.328 ± 0.027

0.308 ± 0.016

0.341 ± 0.036*

0.334 ± 0.044

0.310 ± 0.016

0.362 ± 0.025**

0.341 ± 0.032

0.302 ± 0.018

Lung

Male

1.782 ± 0.201

1.831 ± 0.271

1.845 ± 0.237

1.862 ± 0.779

1.876 ± 0.246

1.910 ± 0.094

1.528 ± 0.103*

1.930 ± 0.088

1.916 ± 0.052

1.516 ± 0.066*

1.898 ± 0.127

2.099 ± 0.322

Female

1.210 ± 0.061

1.434 ± 0.110

1.409 ± 0.098

1.506 ± 0.538

1.449 ± 0.168

1.28 ± 0.062*

1.210 ± 0.072

1.438 ± 0.166

1.419 ± 0.048

1.204 ± 0.192

1.443 ± 0.138

1.503 ± 0.152

% to body weight

Male

0.366 ± 0.038

0.304 ± 0.041

0.289 ± 0.025

0.354 ± 0.087

0.296 ± 0.034

0.287 ± 0.033

0.318 ± 0.021*

0.310 ± 0.029

0.291 ± 0.016

0.316 ± 0.026

0.300 ± 0.028

0.303 ± 0.035

Female

0.416 ± 0.024

0.434 ± 0.036

0.418 ± 0.043

0.537 ± 0.189

0.438 ± 0.064

0.394 ± 0.041

0.456 ± 0.037

0.466 ± 0.036

0.446 ± 0.025

0.447 ± 0.021

0.450 ± 0.048

0.448 ± 0.041

Liver

Male

11.492 ± 1.894

12.852 ± 1.753

14.019 ± 2.841

12.564 ± 3.570

13.450 ± 1.903

14.001 ± 1.859

11.882 ± 1.267

14.860 ± 2.256*

15.212 ± 1.286

11.380 ± 0.892

16.043 ± 3.106*

16.306 ± 1.798

Female

6.885 ± 0.495

8.213 ± 1.184

7.582 ± 0.862

7.057 ± 0.719

8.522 ± 0.984

7.761 ± 1.048

6.920 ± 0.305

8.136 ± 0.742

7.659 ± 0.794

7.356 ± 1.218

8.733 ± 0.742

7.594 ± 0.724

% to body weight

Male

2.356 ± 0.312

2.125 ± 0.125

2.180 ± 0.190

2.407 ± 0.256

2.117 ± 0.187

2.084 ± 0.143

2.461 ± 0.062

2.363 ± 0.209**

2.301 ± 0.061

2.366 ± 0.123

2.498 ± 0.193**

2.357 ± 0.164

Female

2.369 ± 0.223

2.481 ± 0.355

2.239 ± 0.151

2.510 ± 0.189

2.561 ± 0.237

2.351 ± 0.132

2.605 ± 0.169

2.644 ± 0.205

2.402 ± 0.171

2.728 ± 0.105*

2.728 ± 0.300

2.258 ± 0.159

Spleen

Male

0.614 ± 0.042

0.799 ± 0.116

0.833 ± 0.115

0.639 ± 0.105

0.849 ± 0.110

0.795 ± 0.096

0.708 ± 0.166

0.810 ± 0.115

0.868 ± 0.133

0.673 ± 0.073

0.916 ± 0.101*

0.859 ± 0.104

Female

0.431 ± 0.023

0.618 ± 0.149

0.582 ± 0.108

0.460 ± 0.054

0.544 ± 0.074

0.553 ± 0.060

0.478 ± 0.035

0.574 ± 0.115

0.545 ± 0.035

0.446 ± 0.081

0.518 ± 0.080

0.543 ± 0.057

% to body weight

Male

0.126 ± 0.006

0.133 ± 0.022

0.130 ± 0.009

0.126 ± 0.021

0.134 ± 0.009

0.118 ± 0.007

0.147 ± 0.030

0.129 ± 0.009

0.131 ± 0.018

0.140 ± 0.015

0.145 ± 0.015

0.124 ± 0.009

Female

0.148 ± 0.009

0.187 ± 0.046

0.172 ± 0.026

0.164 ± 0.020

0.164 ± 0.021

0.168 ± 0.013

0.180 ± 0.016**

0.186 ± 0.033

0.171 ± 0.006

0.167 ± 0.028

0.162 ± 0.026

0.162 ± 0.018

Kidney

Male

2.832 ± 0.228

3.343 ± 0.322

3.406 ± 0.309

2.943 ± 0.433

3.421 ± 0.481

3.449 ± 0.451

2.766 ± 0.141

3.519 ± 0.316

3.856 ± 0.456

3.013 ± 0.428

3.622 ± 0.410

4.178 ± 0.503*

Female

1.655 ± 0.139

1.896 ± 0.164

1.868 ± 0.199

1.568 ± 0.152

1.932 ± 0.175

1.914 ± 0.255

1.605 ± 0.045

1.978 ± 0.175

1.892 ± 0.111

1.626 ± 0.192

2.025 ± 0.164

1.857 ± 0.167

% to body weight

Male

0.582 ± 0.031

0.557 ± 0.056

0.537 ± 0.060

0.577 ± 0.070

0.540 ± 0.072

0.513 ± 0.029

0.577 ± 0.058

0.563 ± 0.048

0.584 ± 0.062

0.624 ± 0.059

0.572 ± 0.059

0.603 ± 0.026

Female

0.569 ± 0.052

0.574 ± 0.058

0.552 ± 0.031

0.558 ± 0.048

0.582 ± 0.054

0.581 ± 0.049

0.604 ± 0.027

0.643 ± 0.049**

0.594 ± 0.024*

0.606 ± 0.029*

0.632 ± 0.056

0.552 ± 0.034

Adrenal grand

Male

0.068 ± 0.012

0.050 ± 0.006

0.062 ± 0.009

0.059 ± 0.013

0.056 ± 0.007

0.051 ± 0.005*

0.062 ± 0.012

0.055 ± 0.009

0.057 ± 0.005

0.053 ± 0.009*

0.056 ± 0.008

0.065 ± 0.010

Female

0.066 ± 0.007

0.063 ± 0.009

0.067 ± 0.009

0.061 ± 0.009

0.063 ± 0.008

0.055 ± 0.006*

0.066 ± 0.006

0.065 ± 0.012

0.064 ± 0.011

0.061 ± 0.008

0.069 ± 0.009

0.057 ± 0.010

% to body weight

Male

0.014 ± 0.002

0.008 ± 0.002

0.010 ± 0.001

0.012 ± 0.004

0.009 ± 0.001

0.008 ± 0.001*

0.013 ± 0.003

0.009 ± 0.002

0.009 ± 0.001

0.011 ± 0.002

0.009 ± 0.002

0.009 ± 0.001

Female

0.023 ± 0.002

0.019 ± 0.003

0.020 ± 0.002

0.022 ± 0.003

0.019 ± 0.003

0.017 ± 0.001*

0.025 ± 0.003

0.021 ± 0.004

0.020 ± 0.004

0.023 ± 0.004

0.022 ± 0.003

0.017 ± 0.003

Testis(Rt.)/ Ovary (Lt.)

Male

3.391 ± 0.243

3.669 ± 0.398

3.767 ± 0.306

3.607 ± 0.142

3.606 ± 0.788

3.666 ± 0.315

3.324 ± 0.689

3.831 ± 0.472

3.822 ± 0.331

3.594 ± 0.362

3.632 ± 0.851

4.047 ± 0.343

Female

3.594 ± 0.362

0.146 ± 0.030

0.164 ± 0.049

0.145 ± 0.017

0.157 ± 0.038

0.157 ± 0.047

0.149 ± 0.017

0.156 ± 0.022

0.152 ± 0.016

0.148 ± 0.018

0.166 ± 0.036

0.164 ± 0.017

% to body weight

Male

0.698 ± 0.052

0.610 ± 0.054

0.593 ± 0.050

0.716 ± 0.109

0.567 ± 0.109

0.548 ± 0.033

0.684 ± 0.095

0.613 ± 0.079

0.579 ± 0.032

0.751 ± 0.114

0.571 ± 0.128

0.587 ± 0.046

Female

0.046 ± 0.007

0.044 ± 0.010

0.048 ± 0.014

0.051 ± 0.005*

0.048 ± 0.013

0.049 ± 0.015

0.056 ± 0.007*

0.051 ± 0.006

0.048 ± 0.006

0.055 ± 0.002

0.052 ± 0.010

0.049 ± 0.006

Epididymis (Lt.)/Uterus

Male

1.264 ± 0.099

1.542 ± 0.205

1.555 ± 0.142

1.440 ± 0.207

1.547 ± 0.329

1.562 ± 0.403

1.322 ± 0.170

1.550 ± 0.306

1.575 ± 0.170

1.431 ± 0.080*

1.511 ± 0.271

1.669 ± 0.262

Female

0.649 ± 0.173

0.803 ± 0.289

0.883 ± 0.114

0.879 ± 0.283

0.991 ± 0.340

0.970 ± 0.274

0.715 ± 0.195

0.907 ± 0.213

0.691 ± 0.152

0.752 ± 0.338

0.770 ± 0.264

0.893 ± 0.365

% to body weight

Male

0.260 ± 0.021

0.260 ± 0.054

0.245 ± 0.026

0.285 ± 0.050

0.244 ± 0.047

0.231 ± 0.043

0.273 ± 0.015

0.248 ± 0.050

0.239 ± 0.032

0.299 ± 0.035

0.240 ± 0.053

0.241 ± 0.029

 

Female

0.225 ± 0.070

0.245 ± 0.092

0.264 ± 0.048

0.315 ± 0.108

0.299 ± 0.102

0.296 ± 0.084

0.269 ± 0.074

0.298 ± 0.082

0.217 ± 0.044

0.272 ± 0.084

0.240 ± 0.082

0.271 ± 0.125

  1. Note: Data represents body weights right before necropsy, after fasting; Values are mean ± S.D. (n = 5 (4 weeks or recovery), 10 (26 weeks), recovery (30 weeks)/sex/dose). * P < 0.05 & ** P < 0.01 compared with normal group.