Antiprotozoal and antimycobacterial activities of Persea americana seeds

Table 2 Antimycobacterial effect of the CHCl ₃ and EtOH extracts from Persea americana seeds

Mycobacterium tuberculosis	Drug-resistance pattern	MIC (μg/ml)
		CHCl₃extract	EtOH extract
H37Rv	INH-, RIF-, STR-, and EMB- susceptible	50	>100
Clinical isolates
SIN4	STR, INH, RIF, EMB, RFB, ETH, and OFX	50	>100
MMDO	INH, EMB	100	>100
Mono-resistant
RIF-R	RIF	>100	>100
INH-R	INH	50	>100
STR-R	STR	50	50
EMB-R	EMB	50	50
NTB Mycobacterium
M. fortuitum		50	100
M. avium		25	100
M. chelonae		100	100
M. smegmatis		12.5	25
M. abscessus		25	100

SIN 4 MDR clinical isolate of M. tuberculosis resistant to STR: Streptomycin, INH: Isoniazid, RIF: Rifampicin, EMB: Ethambutol, RFB: Rifabutin, ETH: Ethionamide and OFX: Ofloxacin. MMDO MDR clinical isolates of M. tuberculosis resistant to INH and EMB; the resistance pattern was determined by Microdilution alamar blue assay (MABA). NTB: non-tuberculosis mycobacteria; MIC: Minimum inhibitory concentration. Data are means of three determinations.

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